Meta-analysis Of Shensong Yangxin Capsule In The Treatment Of Insomnia

OBJECTIVE: To evaluate the efficacy of Shensong Yangxin Capsule as a single drug or combined with western medicine in the treatment of insomnia.METHODS: Seven databases including CBM,VIP,CNKI,Wang Fang Data,Pub Med,Web of science and The Cochrane Library were searched by computer.All databases were collected from the time of establishment to November 30,2018.Randomized controlled trials of Shensong Yangxin Capsule in the treatment of insomnia were comprehensively collected.Literature screening and data extraction were carried out independently by two researchers,and checked after completion.If the opinions were different,the final results could be negotiated between the two or decided by a third researcher.Using Rev Man 5.3 statistical software for meta-analysis,adverse reactions and recurrence rates were briefly described.RESULTS: The meta-analysis included 15 randomized controlled clinical trials(RCTs),the quality of the included literature is generally low.Compared with conventional western medicine for insomnia,the Shensong Yangxin Capsule group could significantly improve the effectiveness of the evaluation criteria based on the clinical guidelines of new Chinese medicine for insomnia[RR = 4.08,95%,CI(2.61,6.39),P < 0.00001],and significantly reduce the PSQI score [WMD=-2.86,95% CI(-3.67,-2.04),P < 0.00001],however,in terms of improving the efficiency according to the standard of clinical efficacy of sleep,there was no obvious difference between Shensong Yangxin Capsule group and routine western medicine group [RR = 0.57,95%CI(0.27,1.20),P= 0.14],which may be related to too few samples or too short observation time.It also reflects that clinicians pay little attention to cognitive behavioral therapy for insomnia.Compared with conventional western medicine for insomnia,Shensong Yangxin Capsule combined with western medicine group could significantly reduce PSQI score [WMD=-2.75,95% CI(-2.93,-2.56),P< 0.00001].CONCLUSION: This systematic evaluation shows that Shensong Yangxin Capsule can be used as a single drug or combined with western medicine in the treatment of insomnia,and confirms its effectiveness and safety in the treatment of insomnia.