Therapeutic Effect Observation Of Helicobacter Pylori Eradication On Functional Dyspepsia

BackgroundFunctional dyspepsia?FD?is mainly caused by gastric and duodenal dysfunction,the feeling of after-dinner fullness,early fullness,upper abdominal pain and the burning sensation of the upper abdomen.,a set of clinical syndromes of non-functional diseases.FD disease is chronic,delayed,symptoms can be sustained or repeated seizures.The routine treatment of FD mostly uses drug symptomatic treatment,which can make some patients get relief,However,from the actual clinical efficacy,the effect of simple use of symptomatic support therapy is very limited,and the recurrence rate is high.Patients need multiple visits,seriously affecting the physical and mental condition of patients,while increasing their financial burden.Some experts believe that Helicobacter pylori infection and functional dyspepsia are closely related,Eradication of Helicobacter pylori?HP?treatment can significantly improve the symptoms of FD patients,obtain long-term clinical remission,shorten the course of treatment,improve the quality of life of patients.However other scholars believe that Helicobacter pylori infection and Functional dyspepsia have no inevitable relationship.The exact relationship between Helicobacter pylori infection and functional dyspepsia has yet to be further studied.Objective1.In this study,patients with Helicobacter pylori infection complicated with functional dyspepsia were selected as the research object to analyze the general situation and symptom credit type of patients.2.To explore the effect of eradicating hp on clinical symptoms in patients with functional dyspepsia combined with Helicobacter pylori infection.3.Observation and comparison of the eradication of Helicobacter pylori treatment and routine symptomatic treatment of functional dyspepsia Hp eradication rate,symptom remission and treatment safety,for the clinical rational use of drugs to provide reference.Methods1.Collection of 80 cases of FD patients in outpatient and inpatient clinics of the first affiliated Hospital of Xinxiang Medical College,all patients diagnosed with functional dyspepsia by Roman IV standard,rapid urea enzyme test under C¹³-urt or gastroscopy,biopsy pathologic diagnosis of Helicobacter pylori infection,The general condition and symptom type of the patients were analyzed and compared.2.Randomized parallel controlled test design was adopted.The patients were randomly divided into observation group and control group.The control group was given multi-domperidone ketone tablets?10mgTid?+lansoprazole?30mgBid?,and the observation group was given lansoprazole?30mgBid?+claramycin tablets?0.5gBid?+colloidal pectin Bismuth capsules?0.2g Bid?+metronidazole tablets?0.4gBid?,and all around the treatment,before treatment and after 2 weeks treatment and 4 weeks after the treatment of 2 groups of patients after the meal fullness,early fullness,upper abdomen discomfort,upper abdominal pain,heartburn,nausea,vomiting,belching and other symptoms of a questionnaire survey,the symptoms of the score,calculate the total score,and statistical analysis.This research program has been approved by the Institute and the above ethics committee,all patients are aware of this study,voluntary signing of informed consent.Results1.Of the 80 FD combined with HP infection patients with the Roman IV diagnostic criteria,the average age of onset was 47.95±11.171 years,the oldest 70years and the youngest 20 years.Of these,39 cases?48.7%?were males and 41 cases?51.3%?were females.FD patients can become ill in all ages,with more female patients than men.It is common at the age of 36-49,with a ratio of 1:1.051 to men and women.There was no statistical difference in sex and age between the two groups.2.Among the subtypes of functional dyspepsia combined with HP infection,22cases?27.50%?belonged to Upper abdominal pain syndrome,of which 9 cases?23.08%?were males and 13 cases|?31.71%?were females;19 cases?23.75%?were post-meal discomfort syndrome,of which 8 cases?20.51%?were males and 11cases?26.83%?were females;39 cases?48.75%?belongs to the superposition type of upper abdominal pain syndrome and post-meal discomfort syndrome,of which males 22 cases?56.41%?and females 17 cases?41.46%?.In 80 patients with functional dyspepsia,EPS merge PDS overlay type was more common,EPS was the second and PDS was the least.There was no significant difference between the two groups of FD.3.After two weeks of administration,the main clinical symptoms of FD before and after treatment were compared between the two groups,including:postoperative fullness,early fullness,upper abdominal pain,burning sensation of upper abdomen,upper abdominal discomfort,nausea,vomiting,and belching.After two weeks of treatment,the observation group had significant statistical significance in eight aspects compared with the improvement of pre-drug symptoms?P<0.05?.The control group had only six symptoms of postoperative fullness,early fullness,upper abdominal pain,heartburn,nausea and vomiting,which was statistically significant?P<0.05?.However,there was no statistically significant improvement in symptoms in upper abdominal discomfort and belching?P>0.05?.The above data shows that the observation group was superior to the control group in improving the main clinical symptoms.4.After two weeks of eradication of HP treatment in methods combined treatment of four drugs,the observation group had better effect on the remission of functional dyspepsia symptoms than the conventional symptomatic treatment in the control group.The symptoms of the observation group after two weeks of treatment and 4 weeks after the withdrawal of the drug were always effective?82.5%,55.0%?,respectively,higher than the control group?57.5%,40.0%?.The difference is statistically significant.The total effective rate after 4 weeks of withdrawal was lower than two weeks after treatment.5.After 4 weeks of withdrawal,C¹33 urea exhalation test was done for two groups of patients.The results showed that the observation group of quadruple anti-Helicobacter pylori treatment,36 cases of HP test negative,eradication rate of90%.In the control group,17 cases of HP were tested negative,the eradication rate with 42.5%,Through the card side inspection,??²=20.182,P<0.05?.There was significant statistical significance between the two groups.The HP eradication rate of the observation group was better than that of the control group.There was no statistical difference between the two groups compared to the baseline.There were significant differences in HP eradication rates between the two groups?P<0.05?.6.Two groups of patients did not have serious adverse reactions during the course of their medication.In the observation group,1 case of skin itching,1 case of transient vomiting aggravated,1 case of diarrhea.In the control group,5 cases showed poor appetite,abdominal distension and nausea,and vomiting.The incidence of adverse reactions in the two groups was 7.5%and 12.5%,respectively,and there was no significant difference between the two groups before and after treatment?P>0.05?.Conclusion1.After two weeks of eradication of HP treatment with methods of combined treatment of four drugs,the observation group had better effect on the remission of functional dyspepsia symptoms than the conventional symptomatic treatment in the control group.2.The two-week course of quadruple therapy with methods of combined treatment of four drugs in the observation group had an ideal eradication rate for patients who were first HP eradicated.3.The eradication of HP treatment with quadri-combination therapy can significantly reduce the incidence of adverse reactions in patients,improve the prognosis of patients,and it is a safe and effective treatment for FD with HP.