| Objective1. To explore the effect of rabeprazole combined with tetracycline,furazolidone and bismuth potassium citrate on the clinical symptoms of helicobacter pylori(Hp) positive functional dyspepsia(FD) patients.2. To certain the effect of Hp eradication on the gastric electrophysiology in Hp positive FD patients.Methods1. Bioimpedance technique based on wavelet transform was used to observe the gastric electrical activity and impedance of healthy volunteers(n=30) with normal gastric motility, which was determined by semi-solid nuclide method.2. The symptom integral method and gastric motility detection instrument was used to observe the effects of quadruple therapy[rabeprazole with(10 mg bid) + furazolidone(0.1g bid) + tetracycline(0.5g TID) + bismuth potassium citrate(0.22 g bid), for 10d] and rabeprazole(10mg bid, for 10d) on the clinical symptoms and gastric electrical activityand gastric impedance in Hp positive FD patients(n=126).3. Hp infection was determined by the 13C-urea breath test(13C-Urea Breath, Test, 13C-UBT).Results1. The Hp eradication rate in quadruple therapy group of patients with FD was 93.75%. The symptom effective rate of quadruple therapy group at2 and 6 weeks after treatment(67.19%, 59.38%), were significantly higher than those of the rabeprazole group(29.03%, 22.58%)(P < 0.01),respectively. There was no significant difference of the symptom effective rate at both groups between 2 weeks and 6 weeks(P > 0.05).2. In Hp eradication patients, the total effective rates of EPS, PDS,and EPS+PDS at 2w after treatment, were 75.00%, 66.67%, 65.63%, and which has no significant difference among subgroups(P>0.05). The total effective rates at 6w after treatment were 62.50%, 58.33%,59.38%, and which has no significant difference among subgroups(P>0.05).The total effective rate in all FD subtype 6w after treatment was lower than that at the 2w after treatment, but has no significant difference(P> 0.05).3. Before treatment, there was no significant difference in low frequency [(35.05±2.21)% vs(34.89±2.02)%],intermediate frequency[(51.73±3.49)% vs(1.51±3.20)%] and high frequency percentage[(13.22±0.83)% vs(13.60±0.98)%] of the EGG between quadruple therapygroup and rabeprazole group(P>0.05).4. Before treatment, there was no significant difference in low frequency [(35.95±2.21)% vs(35.73±2.76)%], intermediate frequency[(51.06±3.09)% vs(51.15 ± 3.18)%] and high frequency percentage[(13.01±2.38)% vs(13.14±1.95)%] of the IGM between quadruple therapy group and Rabeprazole group(P> 0.05).5. At 2w after treatment, the EGG low frequency in quadruple t-herapy group was significantly lower than that of rabeprazole group[(31.77±2.81)% vs(33.43±2.02)%](P<0.05), the intermediate frequency of EGG was higher than that of rabeprazole group [(55.03±4.18)% vs(52.80±3.12)%](P<0.05), the high frequency of EGG [(13.80±1.40)% vs(13.77±1.11)%] has no marked difference(P>0.05). At 6w after treatment, the low frequency of EGG in quadruple therapy grou-p was markedly lower than that of rabeprazole group[(31.59±2.55)%vs(33.47±1.82)%](P<0.05),the intermediate frequency of EGG significantly was higher than that of rabeprazole group [(54.72±3.72)% vs(52.45±3.23)%](P<0.05), the high frequency of EGG[(13.69±1.23)%vs(14.58±1.15)%] between quadruple therapy group and Rabeprazole group has no significant difference(P>0.05); The EGG parameters of both groups at 6w after treatment has no further improvement than that of 2w(P>0.05).6. Two weeks after treatment, compared to rabeprazole group, the lowfrequency of IGM in quadruple therapy group [(32.74±2.87)% vs(34.55±3.27)%] was lower(P<0.05),the intermediate frequency of IGM was higher [(53.90±3.80)% vs(51.37±4.26)%](P < 0.05), and the high frequency of IGM[(13.33±2.02)% vs(14.17±3.53)%] has no significant difference(P>0.05); 6w after treatment, compared with Rabeprazole group,the low frequency of IGM in the quadruple therapy group was lower[(32.74±2.87)% vs(34.55±3.27)%](P<0.05),the intermediate frequency of IGM was higher [(53.90±3.80)% vs(52.31±4.26)%](P<0.05), the high frequency of EGG[(13.33±2.02)% vs(13.14±3.53)%] has no markedly difference(P > 0.05). There was no significant difference in IGM parameters between two groups at 2w and 6w after treatment(P>0.05).7. According to the 95% CI of EGG parameters in healthy volunteers with the normal gastric semi-solid emptying, the rate of normal EGG in Hp eradicated group(80.00% vs 23.33%) was significantly increased(P<0.01)at 2 weeks after treatment, which was higher than that in 6 weeks after treatment(75.00%),but with no significantly difference(P>0.05).8. Acoriding to the 95% CI of IGM parameters in healthy volunteers with the normal gastric semi-solid emptying, the rate of normal IGM in Hp eradicated group(58.33%) was increased than that(25.00%) at two weeks after treatment(P < 0.01), which was higher than that in 6 weeks after treatment(48.33%),but with no significantly difference(P>0.05).Conclusion1. The quadruple therapy(rabeprazole, furazolidone, tetracycline and bismuth potassium citrate) is safe and effective in Hp positive FD patients.2. Hp eradication therapy can significantly improve the clinical symptoms and gastric electrophysiology of Hp positive FD patients.3. The gastric electrophysiology abnormalities induced by Hp infection may be one pathogenesis of the Hp positive FD. |
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