Clinical Study On Correlation Between Hypercoagulable State Of Advanced Lung Cancer And TCM Syndromes

Objective:A retrospective study was conducted to collect clinical data of advanced lung cancer patients with hypercoagulable state,and to analyze the correlation between TCM syndromes and coagulation index,pathological type and metastasis.Material and Method:From January 2017 to December 2018,85 inpatients of Oncology Department of Suqian Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine were selected to collect their clinical data.The data were analyzed by Microsoft Excel 2010 software and SPSS 22.0 software.The difference was significant if P<0.05 and statistically significant with P<0.01.Results:1.Age distribution:There was no significant difference in average age between men and women in 85 patients with advanced lung cancer with hypercoagulable state(P>0.05);the overall age of onset accorded with normal distribution,mainly concentrated in 65-75 years old.2.TCM syndromes:(1)Distribution of syndromes:26 cases of Qi deficiency syndrome,23 cases of blood stasis syndrome,21 cases of Yin deficiency syndrome,17 cases of Qi stagnation syndrome,12 cases of phlegm-dampness syndrome,10 cases of phlegm-heat syndrome,5 cases of heat toxin syndrome,4 cases of blood deficiency syndrome and 1 case of Yang deficiency syndrome.(2)Comparison of coagulation indexes between syndromes:?Fibrinogen:Compared with Qi deficiency group,Qi stagnation group,blood stasis group and phlegm-dampness group,phlegm-heat group and Qi stagnation group,P<0.05;compared with heat toxicity group,P<0.05.?D-dimer:Compared with Qi stagnation group,phlegm-dampness group and phlegm-heat group,blood stasis group was P<0.05;compared with Qi deficiency group and Yin deficiency group,P<0.01;Yin deficiency group was P<0.05,compared with Qi stagnation group,P<0.01.?Platelet:comparison of each group P>0.05.3.Pathological types and TCM syndromes:(1)Pathological types:43 cases of adenocarcinoma,25 cases of squamous cell carcinoma,16 cases of small cell carcinoma and 1 case of large cell carcinoma.(2)Comparisons of coagulation indices between pathologica l types:Fibrinogen and D-dimer:comparison of each group P>0.05;platelet:adenocarcinoma group and squamous cell carcinoma group were larger than small cell carcinoma group,P<0.05.(3)correlation:?Positive correlation(more likely to occur):adenocarcinoma-blood stasis syndrome,phlegm-dampness syndrome;Squamous cell carcinoma-phlegm-heat syndrome,heat-toxicity syndrome;Small cell carcinoma-Qi deficiency syndrome,Yin deficiency syndrome.?Negative correlation(not easy to appear):adenocarcinoma-yin deficiency syndrome,heat toxicity syndrome;squamous cell carcinoma-blood deficiency syndrome;small cellcarcinoma-blood stasis syndrome.4.Transfer and TCM syndromes:(1)Metastasis:lymph node metastasis 52 cases,bone metastasis 33 cases,pleural metastasis 12 cases,brain metastasis 10 cases,liver metastasis 9 cases,lung metastasis 8 cases,adrenal metastasis 6 cases,spleen metastasis 1 case.(2)There was no significant correlation between fibrinogen and platelet values and the number of metastasis sites.The value of D-dimer increased with the number of metastasis sites,P<0.05.(3)Correlation:?Positive correlation:Lymph node-Yin deficiency syndrome;Bone-blood stasis syndrome,phlegm-heat syndrome,Qi stagnation syndrome;Pleura-heat toxicity syndrome;Brain-phlegm-dampness syndrome;Liver-blood stasis syndrome,blood deficiency syndrome;Lung-blood stasis syndrome,heat toxicity syndrome;Adrenal-Qi deficiency syndrome.?Negative correlation:lymph node-phlegm-dampness syndrome;bone-yin deficiency syndrome;brain-yin deficiency syndrome;liver-yin deficiency syndrome;adrenal-phlegm-dampness syndrome,phlegm-heat syndrome.Conclusion:1.The hypercoagulable state of advanced lung cancer is related to the elevation of fibrinogen and D-dimer in patients with phlegm-heat syndrome,heat-toxin syndrome and blood stasis syndrome.2.For patients with advanced lung cancer,those with blood stasis,phlegm-heat,heat-toxin or adenocarcinoma,squamous cell carcinoma or bone,liver,lung,pleura metastasis and more metastasis sites have a relatively high risk of hypercoagulability.3.For advanced lung cancer patients with hypercoagulable state,attention should be paid to strengthening heat clearance and detoxification,resolving phlegm and removing blood stasis.