Effect Of Neoglitaxin On Advanced Gastric Cancer Complicated With Hypercoagulable State Of Blood

ObjectiveUsing randomized controlled clinical trial, to evaluate the clinical efficacy and security of Modified Liang-Fu Granule( MLFG), in treating the gastric cancer patients combined with hypercoagulable state.Modified Liang-Fu Granule (MLFG) is the experimental drug., compared with western medicine group (control group), to evaluate the clinical efficacy and security of western medicine joint with MLFG group (treatment group), in treating the gastric cancer patients combined with hypercoagulable state.MethodsUsing multi-center, prospective, randomized controlled clinical trial. Patient fully met the inclusion criteria for the study. Pressing 2:1 proportion of patients will be using central randomization method randomly divided into two groups, that is the basis of Western medicine therapy combined with MLFG group (treatment group) and western medicine group (control group).The MLGF, one bag each time,2 times a day. Laboratory indexes related to coagulation (PT, APTT, FIB, DD, PLT, MPV, PDW), blood stasis of TCM symptom score, syndromes, symptoms of efficacy, KPS score, HCS incidence and thromboembolic events were observed indicators. Two groups of patients were observed three weeks to evaluate the effect of the end of the observation.ResultsThis topic is actually included in 75 cases. Treatment group has 52 cases,9 cases of loss; the control group has 23 cases,4 cases of loss. Patients were included in the statistical analysis of a total of 62 cases, including 43 cases of the treatment group and 19 cases of the control group. ① Laboratory indexes related to coagulation (PT, APTT, FIB, DD, PLT, MPV, PDW):After the treatment, the two group all have statistically significant difference in PT(P <0.05); the rest indicators of coagulation were no statistically significant difference (P>0.05).After the treatment, two groups of coagulation difference d(d=after treatment-before treatment)have no statistically significant difference (P> 0.05). ② Hypercoagulable state incidence:After the treatment, the two groups all have no statistically significant difference in hypercoagulable state incidence (P> 0.05); Hypercoagulable state after treatment showed no statistically significant incidence in two groups (P> 0.05). ③ TCM symptoms and signs scores:After the treatment, the treatment group has statistically significant difference in dull, weakness, body pain, skin armour fault, numbness of limbs and all TCM symptom score(P <0.05), after treatment compared with before treatment improved. After the treatment, the control group has statistically significant difference in subcutaneous ecchymosis, depression scores (P<0.05), with subcutaneous ecchymosis improving, but the depression progress. After the treatment, the treatment group has statistically significant difference compared with the control in TCM symptom score (P<0.05), the efficacy of the treatment group is better than the control group. ④ Syndromes and symptoms curative effect evaluation:There is statistical significance difference in the two groups after treatment of TCM syndrome curative effect difference (P< 0.05), and the treatment group improved is better than that of the control group. After the treatment, there is statistically significance difference in the two groups in dull, weakness, subcutaneous ecchymos (P<0.05), the treatment group curative effect is better than the control group. No significant differences in symptom curative effect evaluation of the remaining (P>0.05). ⑤ KPS score and efficacy:The two groups all could improve the quality of life of patients (P<0.05), but the efficacy of the treatment group was better (P<0.05). ⑥ Thrombotic events:The control group of 1 patient with thrombotic events, but no statistically significant difference between two groups (P>0.05).⑦ MLFG has good safety.ConclusionConclusion the treatment: ① MLFG can improve the blood stasis syndrome of gastric cancer (gastric cancer complicated with blood hypercoagulable state)in patients with dull, weakness, subcutaneous ecchymosis and so on, and reduce the total symptoms score of Qi deficiency and blood stasis syndrome symptoms and signs, with the improvement of Qi deficiency and blood stasis syndrome curative effect. ② MLFG can improve the quality of life in patients with gastric cancer. ③ MLFG can improve and prevent the hypercoagulable state in patients with blood, and has great significance for the prevention of thromboembolic events.