The Clinical Observation Of Shu-Gan-Xie-Huo Decoction In The Treatment Of Post-stroke Depression (Qiyuhuahuo Type)

Objective:In order to evaluate the clinical effect of traditional Chinese medicine treatment on post-stroke depression patients,we used Shu-Gan-Xie-Huo decoction to treat PSD(Qiyuhuahuo type)of post-stroke depression and compared it with sertraline hydrochloride tablets.Methods:Based on inclusion and exclusion criteria,108 patients with post-stroke depression in outpatient or inpatient departments of Hubei Traditional Chinese Medicine Hospital from January 2018 to December 2018 were collected.According to random number table method,they were divided into treatment group and control group,54 cases in each group.The treatment group was given Shu-Gan-Xie-Huo decoction,while the control group was given Sertraline for four weeks.The TCM syndromes of the two groups before and after treatment were observed.The scores of HAMD,NIHSS and ADL were analyzed by SPSS21.0 software.Results:(1)Compared the clinical efficacy of TCM syndromes: After four weeks of treatment,27 cases(50%)were cured in the treatment group,13cases(24%)were markedly effective,9 cases(16.7%)were effective,the curative rate(clinical cure rate + marked efficiency)was 74%,the total effective rate of TCM syndromes in the treatment group was 90.74%,significantly higher than that in the control group,the total effective rate was75.93%.There was significant difference between the two groups(P < 0.05), indicating that the treatment group improved depression,qi depression and fire after stroke(P < 0.05).The curative effect of type A was higher than that of the control group.(2)Compared the clinical efficacy of HAMD scale: After four weeks of treatment,26 cases(48.1%)were cured,14 cases(25.9%)were markedly effective,11 cases(20.3%)were effective,the curative rate(clinical cure rate+ marked efficiency)was 74.0%.The total effective rate of HAMD scale in the treatment group was 94.4%,which was significantly higher than that in the control group(77.8%).The difference between the two groups was significant(P < 0.05),indicating that the treatment group had a significant effect on improving post-stroke depression(P < 0.05).Compared with the control group.(3)Comparisons of TCM syndrome scores: After four weeks of treatment,the score of TCM syndromes in the treatment group was 5.40±4.82,while that in the control group was 10.80±5.74.There was significant difference between the two groups(P < 0.05),suggesting that the treatment group was superior to the control group in improving TCM syndromes of Qiyuhuahuo type.(4)Comparisons of HAMD scale scores: After four weeks of treatment,the HAMD score of the treatment group was 9.53±3.89,while that of the control group was 13.42±4.02.There was a significant difference between the two groups(P < 0.05),indicating that the treatment group was superior to the control group in improving the degree of post-stroke depression.(5)Comparisons of NIHSS scale scores: After four weeks of treatment,the NIHSS score of the treatment group was 4.59±2.89 and that of the control group was 7.26 ± 3.00.There was significant difference between the two groups(P < 0.05).It showed that the treatment group was superior to the control group in improving the neurological deficit in patients with post-stroke depression.(6)Comparisons of ADL scale scores: After four weeks of treatment,the SDSS score of the treatment group was 75.61±11.56 and that of the control group was 62.23±10.46.There was a significant difference between the two groups(P < 0.05),indicating that the treatment group was superior to the control group in improving the daily life activities of patients with post-stroke depression.(7)Safety: In the treatment group,3 patients developed epigastric discomfort after taking the medicine,manifested as nausea and vomiting,and the adverse symptoms disappeared after ordering them to take it after meals.In the control group,2 patients began to suffer from dry mouth,mild diarrhea and other symptoms,and did not stop taking the medicine.After a few days,the adverse symptoms gradually disappeared.Three routine examinations,liver and kidney function and electrocardiogram of 108 patients were in normal range before and after treatment.Conclusion:Shu-Gan-Xie-Huo decoction has a remarkable clinical effect in treating post-stroke depression(Qiyuhuahuo type).It not only improves the symptoms of post-stroke depression,but also helps the rehabilitation of neurological function of patients with stroke.There are no obvious adverse reactions and drug dependence or addiction after treatment.Compared with the control group,Shu-Gan-Xie-Huo decoction has a better clinical therapeutic effect,suggesting that Shu-Gan-Xie-Huo decoction is effective in PSD.It has certain advantages in treatment and deserves further in-depth study.