The Research Of Relevant Risking Factors Of Transient Ischemic Attack With Carotid Stenosis Secondary Cerebral Infarction And Its Prognosis Analysis

Background Transient ischemic attack is a disease of cerebrovascular, which due to the lack of blood supply incarotid and vertebral-basilar artery to temporary, focal cerebral ischemia leads to neurological disorders of sudden, transient, reversible, and may even progresses to complete cerebral infarction, It is a common early warning signals of secondary stroke.Meanwhile, Carotid atherosclerosis stenosis is a common cause of TIA and stroke. Associated with carotid artery stenosis TIA has the poor.prognosis.Objective From the data of carotid artery stenosis that collected from clinical of transient ischemic attack, and through follow-up survey, for carotid stenosis in patients with transient ischemic attack progress, for cerebral infarction as heavy end event by cohort study, unearthed carotid artery in patients with transient ischemic attack to the independent risk factors of cerebral infarction, improve the type of carotid stenosis transient ischemic attack to the anticipation of the risk of cerebral infarction, the implementation of early intervention and develop effective treatments, systemic treatment, reduce the incidence of patients with poor prognosis.Methods Collection the clinical data of patients which treated 126 cases of transient ischemic attack by the neck vascular color from May 2008 to June 2009, a retrospective study, followed up for 5 years. Composite end point events in secondary cerebral infarction or death, divided into secondary cerebral infarction group and no secondary cerebral infarction group and comparison between the two groups of patients with clinical data, including:patients’ age, gender, history of diabetes, history of hypertension, history of smoking smoking (index); On conventional biochemical indexes, including total lymphocyte count, hemoglobin, C-reactive protein, fibrinogen, platelet count, low density lipoprotein cholesterol, creatinine, international standardization ratio; Imaging data:the degree of carotid stenosis. ABCD2 evaluation method, carries on the comparison to two groups of data, assessment of progress for patients with cerebral infarction risk size.Result In the these 126 standard sample cases, Compared to two sets of data, combination of secondary cerebral infarction and hypertension (17.24%), less secondary groups of 15 high 5 (12.82%),p<0.05, the difference was statistically significant; Secondary combination and history of diabetes,12 (13.79%) than the control group 3 (7.69%),p<0.05, the difference was statistically significant; Secondary group average smoking index> 400, 31 (35.63) less secondary groups of 10 people high (25.64), p<0.05, the difference was statistically significant, secondary attack group> 60 min of 30 people (34.48%), less secondary group of 7 people (17.95%) is high, there are statistically significant. Statistically significant. Secondary cerebral infarction group and no secondary cerebral infarction in average ABCD2 score:5.00 points,3.17 points, two groups of x2 test,p<0.05, the difference was statistically significant. On conventional biochemical index, platelet count in patients with secondary cerebral infarction, low density lipoprotein cholesterol (hdl-c), fibrous protein level were less secondary group high, both comparison,p<0.05, the two groups in the carotid artery stenosis degree, secondary group than medium-duty or carotid artery occlusion without secondary high, both comparison,p< 0.05, statistically significant. Secondary cerebral infarction with TIA afterbrain infarction group in general project information, secondary hypertension patients with cerebral infarction group, low density lipoprotein levels lower than simple cerebral infarction group,p<0.05, statistically significant. Secondary cerebral infarction group and simple cerebral infarction group, two groups of GCS score and grade of nerve function defect degree, prognosis, secondary group is higher than simple cerebral infarction group, p< 0.05, statistically significant (p<0.05).Conclusion Overall, Carotid stenosis is the independent risk factors for the prognosis of TIA, TIA with carotid stenosis secondary cerebral infarction will make the risk higher, the merger of carotid stenosis TIA afterbrain infarction associated risk factors including:age >over 60 years old, high blood pressure, diabetes, infection duration> 60 min, smoking index> 400, platelet count, low density lipoprotein levels, fibrous protein levels and the degree of carotid stenosis. Carotid stenosis in patients with TIA (secondary cerebral infarction with poor prognosis.Type of carotid artery TIA patients, early intervention, in a timely manner to assess their risk, system treatment maybe improve the prognosis.