Clinical Study Of Zhang Liangying’s Experience Room Combined With Hormone In The Treatment Of Premature Ovarian Insufficiency With Spleen-Kidney Deficiency

Objective: To observe the effect of Professor Zhang Liangying’s experience formula combined with Climen on Premature Ovarian Insufficiency of spleen and kidney deficiency type and the recurrence rate of 3 months and 6 months after drug withdrawal.To explore the treatment of Zhanglao Bushen Recipe and Tiaojing Recipe with hormone Therapeutic effect of treating Premature Ovarian Insufficiency of spleen and kidney deficiency type,inheriting the experience of famous Chinese medicine practitioners,providing effective and inexpensive,safe and effective treatment for Premature Ovarian Insufficiency.Methods: Sixty-two patients with POI who met the inclusion criteria were randomized into a treatment group of 31 patients and a control group of 31 patients.The treatment group took Zhang Liangying’s experience formula prescription for tonifying kidney and regulating menstruation combined with Climen,and the control group taking keling.Take 3 cycles of menstruation for a total of 3 months,that is,1 course of treatment.Before and after the observation,the hormone measurement,AMH measurement,transvaginal gynecological b-ultrasound and breast bultrasound were performed.The breast b-ultrasound was followed up for three months after drug withdrawal and half a year after drug withdrawal.The symptom score was recorded.And statistical analysis of the above data,summed up the results;comprehensive efficacy,scores(menstrual syndrome scores,systemic symptom scores,total score),curative and safety indicators,and after withdrawal At 3 months,the recurrence of the two groups of patients was compared after half a year,and the clinical efficacy of the two groups was compared.Result:First,Comprehensive efficacy comparison:The total effective rate of the treatment group was 90.32%;the total effective rate of the control group was 83.87%.The difference between the two groups was statistically significant(P<0.05).Second,Chinese medicine clinical symptom score comparison:There were significant differences in menstrual syndrome scores,systemic symptom scores,and total symptom scores between the two groups before and after treatment(P<0.05).There was no significant difference in menstrual syndrome between the two groups after treatment(P>0.05),systemic symptoms,total There was a statistically significant difference in the scores(P<0.01).There was a statistically significant difference between the two groups(P<0.01)in the two groups after 3 months of discontinuation and half a year after discontinuation.Third,the efficacy index FSH,LH,E2,AMH comparison:(1)Comparison of FSH,LH,and E2 There were significant differences between the two groups before and after treatment with FSH,LH,and E2(P<0.05).There was no significant difference between the two groups in the FSH and LH groups(P>0.05),and the E2 group was statistically significant(P<0.05).(2)AMH comparison: The two groups of AMH were compared before and after treatment,and the treatment group was statistically significant(P <0.05).Fourth,AFC(bilateral sum): There was no statistical difference in the two groups before and after treatment(P <0.05),and there was no statistical difference between the two groups after treatment(P> 0.05).Five.Comparison of safety indicators(ALT,AST,Cr,BUN): There were no significant differences between the two groups in the safety index group before and after treatment(P>0.05).Conclusion:First.The combination of Bushen Recipe and Tiaojing Recipe combined with Climen for the treatment of spleen and kidney deficiency type POI is effective;the comprehensive curative effect and long-term curative effect of the treatment group are significantly better than the control group;Second,the two groups in the improvement of menstrual symptoms,hot and sweaty,irritability,vaginal dryness,libido effect is equivalent;the treatment group is improving backache,tinnitus,fatigue,abdominal distention,inattention,urinary frequency The effect is obvious.Third,both groups can improve patients FSH,LH,E2,AMH,AFC;and the treatment group can significantly improve the patient’s E2 and AMH level;...