The Clinicaland Experimental Research Of Liumotang Treatment For Slow Transit Constipation(Intestinal Qi Stagnation Syndrome)

The first part Clinical research of Liumotang treatment of slow transit constipation(Intestinal Qi Stagnation Syndrome).Objective: Liumotang is a prescription commonly used in clinical treatment of slow transit constipation.This study compared the efficacy of lactulose oral liquid with the purpose of exploring the clinical efficacy and application value of Liumotang.Methods: During the period from July 2017 to July 2018,sixty patients who met the criteria were selected as the target of this clinical study.All patients were from the Department of Gastrointestinal Surgery and Inpatient Department of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine.According to the random number table method,randomly divided into two groups,Liumotang group:30 cases,given Liumotang,one dose per day,decoction juice 200 ml,two times orally,every10 days for a course of treatment,taking 2 courses continuously;Lactulose oral liquid group: 30 cases,lactulose oral solution,10 ml / time,three times a day orally,every 10 days for a course of treatment,taking 2 courses.The clinical symptom scores,efficacy results,recurrence rate,and colonic transmission function before and after treatment were recorded before treatment,after 1 course of treatment,after 2 courses of treatment,and after 1month,3 months,and 6 months after the end of treatment.The marker is discharged and analyzed.Results: In the treatment,one patient in the Liumotnag group had adverse drug reactions after taking the drug.After taking the corresponding measures,no relief was observed.After the drug was stopped,the symptoms were relieved.The case fell off,so Liumotang group completed 29 cases,30 cases in the lactulose group.Two groups completed 59 cases.After 2 courses of treatment,the total effective rate of the Liumotang group was 89.66%,and the effective rate of the lactulose group was 80.00%,(P <0.05).The two groups were followed up for 1 month,3 months,and 6 months after treatment.The mean scores of the treatment group were lower than those of the control group.After 1 month follow-up,One patient relapsed and the relapse rate was 3.48%.After 3 months follow-up,3 patients relapsed and the relapse rate was 10.34%.After 6 months follow-up,4 patients relapsed and the relapse rate was 13.79%.The lactulose group was followed up for 1month,2 patients relapsed.The relapse rate was 6.67%.After 3 months follow-up,5 patients relapsed and the relapse rate was 16.67%.After 6months follow-up,8 patients relapsed and relapse rate was 26.67%.(P<0.05).Conclusion: The total effective rate of Liumotang treatment of slow transit constipation was higher than that of lactulose,which could effectively improve clinical symptoms.After the treatment,the recurrence rate of Liumotang group was lower than that of lactulose group.The second part Study on the mechanism of Liumotang from the changes of intestinal flora and gastrointestinal motility in rats with slow transit constipationObjective: The mechanism of Liumotang was studied from the changes of intestinal flora and gastrointestinal motility in rats with slow transit constipation.Methods: Sixty healthy Wistar rats were selected,weighing 110±10g,and 30 females and males.Rats were randomly divided into two groups,15 in the normal group,and 45 in the model group.They were housed in cages and given appropriate temperature and humidity.The normal control group was fed with normal dry feed,not limited to drinking water.45 rats of the model group were given Yimeng stop 10mg/(kg.d),and on the 25 th day of feeding,after taking the feces,0.5ml of 5% charcoal suspension was orally administered,and the recording was started from the end of the gavage.The discharge time of the first black stool in the rats was the intestinal transit time.Compared with the normal control group,the 24 h food intake,water intake,fecal quality and intestinal transit time were analyzed to verify the success of the model.After confirming the successful modeling,they were randomly divided into blank control group,saline control group and experimental treatment group,respectively,and then the intestinal flora(Escherichia coli,Lactobacillus,Bifidobacterium,Enterococcus)was performed on each group of rats.Colony assay,gastrointestinal motor function was measured from gastric residual rate and small intestinal propulsion rate.Results: Easy to stop can effectively inhibit rat bowel movements,prolong the discharge of feces,or difficult to discharge feces.After the administration of Liumotang,the number of Escherichia coli colonies in the intestinal flora of the treatment group was reduced compared with the control group,the number of colonies of Lactobacillus,Bifidobacterium and Enterococcus increased,the gastric residual rate decreased,the intestinal propulsion rate increased,and the intestinal transmission function is improved.Conclusion: Liumotang can effectively improve the intestinal flora of rats with slow transit constipation caused by modeling drugs,and can slow down the effect of drugs on defecation in rats,improve the function of gastrointestinal motility,and adjust the structure of intestinal flora to treat slow transit constipation.