Research On Professor Zhou Zhongying's Experience In Treating Primary Liver Cancer And His Academic Thoughts Based On Data Mining Technology

Research objective:Based on multi-angle and multi-level research on large-scale medical records,through the data mining analysis of medical records and qualitative medical interviews,Professor Zhou Zhongying's clinical experience and academic thoughts in the treatment of primary liver cancer was discussed,then form the primary disease of Zhou Zhongying Clinical plan for liver cancer.Research methods:Through the medical records of the primary liver cancer in the medical record database of the Chinese medicine master Zhou Zhongying's studio,after screening and cleaning,the data were in compliance with the inclusion criteria and the exclusion criteria,including 279 cases(a total of 998 cases).It's Entered Excel 2010 and established a medical record database,It mainly uses frequency analysis,association rules and factor analysis methods,multi-level analysis of syndromes,pathogenesis,and prescriptions of medical records,and summarizes Zhou Zhongying's treatment of primary nature through human-computer combination,typical medical record interpretation,and qualitative medical interviews.Research result:1.data mining analysis results(1)General situation:In 279 cases of primary liver cancer,there were 218 males and 61 females,the oldest being 84 years old and the youngest being 22 years old.The average age is(54.57 ± 12.24)years old.There were 165 cases of chronic hepatitis B history,3 cases of hepatitis C history,83 cases of hepatectomy,5 cases of radiofrequency ablation,103 cases of interventional therapy,92 cases of liver cancer with liver cirrhosis,and 3 cases of liver transplantation.(2)Distribution of syndromes:There were 155 symptoms in 279 cases.The symptoms with frequency above 29 were hypochondriac pain(116),dry mouth(89),anorexia(85),Bloating(80),urinary yellow(77),fatigue(71),ascites(42),gastrectasia(37),dull complexion(34),splenomegaly(33),bulging(30).Among them,the frequency is more than 20 times,the yellow greasy moss(52),the thin yellow greasy moss(49),the thin yellow greasy moss(32),the yellowish greasy moss(26),the dark red color(78),the dark color(66),the dark purple color(60),the red color(32),the crack of the tongue(33),the slippery pulse(54),The pulse is smooth(54),the pulse is fine(41),and the pulse string(21).(3)Distribution of pathogenesis:There are 88 different pathogenesis descriptions in 279 patients' initial medical records,including nature of disease,disease location and pathological factors.Among them,nature of disease belong to excessiveness and deficiency.The virtual ones are yin deficiency(20.79%),qi deficiency(20.07%)is the main.The pathological factors were mainly sputum(93.91%),wet(84.95%),heat(83.7%),cancer(74.91%),and qi stagnation(15.77%),and sputum(7.89%)was rare.The disease location is mainly in the liver and spleen,involving the kidney,stomach,and lungs,and occasionally in the heart.The frequency of common pathogens from high to low is damp heat and phlegm(51.61%),liver and spleen(46.95%),qi and yin deficiency(19.35%),dampness and phlegm stagnation(10.75%),liver and kidney Yin deficiency(8.24%)is the most common,among which the damp heat and phlegm,the liver and spleen account for 43.94%of the total number of pathogenesis,so it can be regarded as the main pathogenesis or basic pathogenesis of primary liver cancer.(4)Distribution of traditional Chinese medicine:242 kinds of drugs in 279 cases,a total of 6074 kinds of times,the frequency of more than 50 times(including 50 times)of the drugs are:Hedyotis diffusa(236),Scutellaria barbata(216),Chicken 's Gizzard-membrane(176),Akebia trifoliata(175),Curcuma zedoaria(167),stone piercing(166),Turtle shell(162),Cremastra appendiculata(151),ginseng(139),Agrimoniae Herba(135),amomum(133),green skin(124),tuckahoe(111),radix ophiopogonis(107),fruit of princesplume ladysthumb(106),Ground Beeltle(106),Euphorbia helioscopia(102),Atractylodes(92),capillary artemisia(95),Rhaponticum(81),Rhizoma Arisaematis(81),Rhizoma pinelliae preparatum(77),dried rehmannia root(77),agaric(76),Solanum nigrum(74),astragali radix(74),Radix Paeoniae Rubra(73),Coix seed(72),medicated leaven(70),Eclipta alba(70),Coastal Glehnia Root(68),dried tangerine(66),Aspongopus(65),ligustrum lucidum ait(63),Centipede(58),toad skin(57),asparagus fern(56),Vinegar entrapement(54),Codonopsis pilosula(52),Cortex Moutan(51),Rhizoma Alismatis(50),licorice(50).(5)Factor analysis:43 drugs with frequency occurrence 50 times or more were analyzed,and 8 common factors were extracted.For example,factor 1 consisted of Hedyotis diifusa,stone penetrating,armor,sage mushroom and earthworm;Factor 2 consists of scorpion,green skin,scorpion and scorpion;factor 3 consists of geranium,coke white,scorpion,codonopsis,and licorice.The 15 pathological factors were analyzed and a total of 4 common factors were extracted.F'or example,factor 1 is sputum,dampness,heat,cancer,liver and spleen.This is the basic pathogenesis of primary liver cancer.Knot,liver and spleen two inj uries.(6)Association rule results:The association rules were used to analyze the relationship between common pathological factors,pathogenesis,symptoms and drugs,a total of 16 groups.Such as:wet related drugs are:Yin Chen,Solanum nigrum,silkworm,white atractylodes,Jiaoshan,cooked rhubarb,dried tangerine peel,Alisma,fried Divine Comedy,French Pinellia.Drugs related to qi and yin deficiency:north and south ginseng,Codonopsis,Shanci mushroom,and coix seed.The drugs related to fatigue fatigue include raw jaundice,agrimony,medlar,and turmeric.2.the results of qualitative interviews with famous doctorsAccording to the data mining results of the medical records,the focus is on clustering and summarizing the syndromes,pathogenesis,treatment and prescriptions in the medical records,and conducting qualitative interviews with famous doctors at any time.The basic principle of Professor Zhou Zhongying's treatment of primary liver cancer is:Oldenlandia Diffusa,scutellariae barbatae,Stone beating,Rhizoma curcumae,Shancigu,taizis,turtle shell,radix pseudostellariae,Agrimonia pilosa,Amomum villosum,Chicken's Gizzard-membrane,Radix Ophiopogonis,Ground Beeltle,euphorbia helioscopia,fabanx,Rhizoma Pinellinae Praeparata,shenghuaq,Astragalus membranaceus.Research conclusions:(1)Professor Zhou Zhongying treats primary liver cancer with a combination of disease and syndrome,focusing on the comprehensive analysis of the compound pathogenesis,that is,paying attention to the pathogenesis syndrome.By grasping the main symptoms,tongue and pulse,physical and chemical examination,to identify the main basis of pathogenesis syndrome(to pathological factors,detailed identification of disease,disease).On this basis,it emphasizes the combination of disease differentiation and syndrome differentiation,clarifies the primary and secondary specimens of liver cancer pathogens,prioritizes them,and then determines the focus of the prescriptions and prescriptions,and according to the syndrome,randomized medication.(2)Professor Zhou proposed that the basic pathogenesis of primary liver cancer is wet heat,phlegm and blood stasis,and liver and spleen injuries.The pathological factor is based on cancer,and it is combined with wet,hot,sputum,sputum,stagnation and other cementation.The disease is mainly in the liver and spleen,involving the gallbladder,stomach,kidney and lung.Most of the pathological properties belong to this virtual standard,and the virtual and real are mixed.(3)Professor Zhou's compound pathogenesis for primary liver cancer,the use of complex method prescriptions in the clinical card,and the early use of the evil spirits to Gu Zheng,using the Qinghua damp heat and scorpion venom method to add anti-cancer detoxification and attack products.Discretion should be added to soothes the liver and spleen,nourish the liver and kidney or supplement the qi and nourish the yin;the middle and late stage of liver cancer is mainly due to qi deficiency,emphasizing the righteousness to help the evil spirits,including Shugan and stomach spleen,nourishing liver and kidney,nourishing yin and clearing heat.The same method,accompanied by Qinghua damp heat,phlegm and blood stasis,blood stasis and soft.In the whole treatment process,it is necessary to pay attention to conditioning the spleen and stomach first,to avoid the decline of the spleen and stomach,but also to avoid the use of Xinxiang walking,blood stasis and phlegm.(4)Through research,the basic formula is formed as a basic syndrome type.In addition,there are still hot and humid stagnation stagnation,? liver and stomach dysfunction,stomach qi stagnation syndrome;?liver stagnation and spleen deficiency,damp heat and phlegm and blood stasis syndrome;?liver and kidney yin deficiency,Damp heat,phlegm and stasis syndrome;?damp heat,phlegm and blood stasis,collateral heat and blood stagnation;?qi and yin deficiency,dampness,heat,phlegm and blood stasis syndrome;?liver and spleen two injuries,soil thief,qi stagnation water stop,damp heat sputum There are 7 common compound syndromes.According to this,each compound syndrome is commonly used in treatment,prescription,addition and subtraction.Finally,the "Clinical Program for the Diagnosis and Treatment of Primary Liver Cancer by Professor Zhou Zhongyu's Pathogenesis"was formed.This study obtained the ideas and experience of Professor Zhou Zhongying in the treatment of primary liver cancer through data mining methods,human-machine combination methods and qualitative interviews with famous doctors.From the medical records,Professor Zhou Zhongying's clinical plan for the treatment of primary liver cancer was summarized,which provided an example for the treatment of primary liver cancer with Chinese medicine.Post-study can be better learned and passed down.