The Experience Key Factors Research On The Chronic Liver Disease Treating By Professor Zhou Zhongying Based On Data Mining

Objective:To summarize Professor Zhou Zhongying's experience key factors in dlagnosing and treating chronic liver disease which arounds the research of law of pathogenesis factors on the basis of his clinic practice for dozens of years and modern data mining technology.Methods:Comprehensively collecting and collating Professor Zhou Zhongying's clinical cases about chronic liver disease in the past 15 years.753 cases which have clear diagnosis and relatively complete records were picked up and established a chronic liver disease database.In order to find out the rules of syndrome,pathogenesis, and medication, data mining technology like frequeneies,factor analysis, association analysis and regression analysis were used.The analysis results were discussed and summarized combined with Professor Zhou's clinical experience.Results:(1) According to frequency analysis, the pathogenesis factors:During chronic hepatitis course,over 40% belong to the efficiency syndromes are dampness,heat,blood stasis, stagnation and toxin, over 20% belong to the deficiency syndromes are Qi deficiency and Yin deficiency,the positions are liver, spleen and kidney.As the disease runs to liver fibrosis and cirrhosis, blood stasis increases to the first pathogenesis factor and the positions spleen increase. (2) The symptoms:The symptoms over 10% are hypochondriac pain,urine,loose stool,dry mouth,fatigue,dull pain,abdominal distension, hypochondriac distension, bitter mouth, dry stool, anorexia, the tongues are yellow coating, greasy coating, dark tongue, thin coating, red tongue, purple tongue, the pulses are thready pulse, slippery pulse, wiry pulse and soggy pulse. These symptoms can be summary to dampness-heat-blood-stasis-toxin compound pathogenesis. (3) The drugs:Totals of 308 drugs are used. Over 30% drugs are Chuchaihu, Chishao, Yinchen, Pugongying, Yujin, Chuipencao, Danshen, Huangqin, Xiangfu, Houpu. Effectiveness of commonly used drugs focuses on clearing away heat and promoting dieresis, detoxication and promoting blood flow, soothing the liver and resolving depression. Most commonly used dosage range in clinical routine usage,but the dosage of Chuchaihu and Houpu less than the dosage of clinical practice and Pugongying more than.The dose change of commonly used drugs except Yinchen and Danshen is small. (4) According to factor analysis, five common divisors of the common pathogenesis factors, twenty-seven common divisors of the common symptoms, fourteen common divisors of the common drugs are extracted. According to association analysis, finding that the most relevant of dampness and soggy pulse, heat and bitter mouth, blood stasis and purple tongue, toxin and hypochondriac dull pain, stagnation and abdominal distension. According to regression analysis, the most commonly used eliminating dampness drug, clearing heat drug, promoting blood flow drug, detoxifying drug, resolving depression drug are Pugongying,Huzhang,Chishao,Sheshecao and Chuchaihu.Conclusions:According to this study, the dampness, heat, blood stasis, toxin and stagnation are pathological key factors.Dampness-heat-blood-stasis-toxin which throughouts the entire course of chronic liver disease often annexe, exchangs and compounds. Qinghua Shireyuduyu is the major therapy to dampness-heat-blood-stasis-toxin compound pathogenesis.