Professor Zhou Zhongying Pathogenesis Differentiation Of Primary Intracranial Tumor Clinical Experience And Academic Thought

Research objective:Based on the multi-angle and multi-link to carry out medical records analysis of data mining and knowledge discovery, comprehensive summary of Professor Zhou Zhongying’s clinical experience and academic idea in treating primary intracranial tumor based on Pathogenesis of syndrome differentiation.The formation of Professor Zhou Zhongying treating primary intracranial tumor pathogenesis clinical program, and refines his academic ideas.Which can give an effective guide to TCM in the application of the comprehensive therapy of primary intracranial tumor, to improve the clinical curative effect.Research methods:Through long time study following in Professor Zhou Zhongying, understanding Professor Zhou Zhongying’s Pathogenesis of syndrome differentiation experience,comprehensive collection and sorting Professor Zhou Zhongying treatment of intracranial tumor medical record during the past 20 years,strictly according to the inclusion criteria, exclusion criteria for selection, will conform to the standard of 226 cases(a total of 1052 cases) of medical record information to establish medical record database.Running frequency method, factor analysis and association rules and so on, multi level mining analysis of medical records in the syndrome, pathogenesis, prescription between the rules.Combined with the deep study of typical cases and medical interview, summarizes Professor Zhou Zhongying’s clinical experience and academic thoughts in treating primary intracranial tumors.Research results:(1) General situation:All the 226 cases of primary intracranial tumor, which 111 are male and 115 are female. The average age is (41.52±18.80) years old.(2)Syndrome distribution:Involving a total of 498 kinds of symptoms,Which the frequency is more than 20 times in order:headache (76),dry mouth (62), blurred vision (58), constipation (40), dizziness (40), vomiting (32), walking instability (26), vertigo (26), anorexia(25), insomnia (22).Involving a total of 64 kinds of tongue and pulse, the frequency of more than 50 times as follows:smooth pulse (89), Huang Boni tongue(66), dark red tongue (59), dark tongue (51).(3)The distribution of Pathogenesis:The first confirmed case with 69 kinds of Pathogenesis.Among them the frequency is greater than 10% in the order:liver and kidney deficiency, the wind phlegm and blood stasis resistance, QingYang disuse, phlegm and blood stasis on.Through the analysis of the pathogenesis of syndrome factors,in the total of 22 kinds of pathogenesis of syndrome factors,the frequency of more than 10% of the disease factors followed by:phlegm, blood stasis, wind, yin deficiency;the disease location factors followed by:liver and kidney.(4)The distribution of commonly used herbs:Herb use frequency statistics:there are 234 herbs in the medical record in all,according to the frequency in turn from high to low the top 20:Batryticated silkworm(206),Bile south star(190),Ze Lan(l 72),Alisma(171),Scorpion(163), Wartwort(150),Mountain arrowhead(141),Rhizoma typhonii(129),Centipede(125),Ajugadecumbens(107),Ge Gen(105),Caulis dendrobii(105),Radix asparagi(105),Rhizoma ligustici wallichii(102),Dew hive(92),Astragalus membranaceus(86),Ground beetle(86),Barbed Skullcap Herb(77),Blackend swallowwort root(75),Ophiopogon japonicus(74).Herb efficacy analysis:Commonly used herbs (refers to the frequency of more than 20 times) involving 49 kinds of herbs,analysis by classification of herb efficacy.the attack evil herb to dispel the wind phlegm, detoxicating and activating the collaterals, dissipating phlegm and dissipating phlegm,blood stasis.promoting blood circulation to remove blood,clearing away heat and toxin, clearing damp and promoting diuresis,respectively accounting for 18.3%,16.32%,16.08%,12.44%,8.46%.The centralizer herbs mainly in nourishing yin and tonifying the kidney, tonifying qi and blood, respectively accounted for 17.98%,4.85%.(5)The herbs factor analysis:Pairs frequencies greater than 20 of 49 herb extract 10 factors reflecting the different combinations of drugs. Factor 2 of the herb consists of:Rhizoma typhonii, Centipede, Scorpion, Dew hive.(6)The results of association analysis:analysis of the common pathological factors or the merge pathogenesis’s relationship with the herbs through the association rules.Such as herbs for associated with the wind:Rhizoma typhonii,Gastrodia elata Blume,Burdock,Barbed Skullcap Herb,AjugadecumbenS,Scorpion,Earthworm,Centiped,Wartwort,Rhizoma acori graminei;herbs associated with the liver and kidney yin deficiency:Glossy privet fruit,Eclipta alba,,Caulis dendrobii,Ophiopogon japonicus,Rehmannia,ile south star,Ze Lan,Alisma.Research Conclusions:(1)Professor Zhou adopt the combination of disease and syndrome differentiation, attaches great importance to the pathogenesis of syndrome differentiation, proposed "liver and kidney deficiency, wind phlegm and blood stasis, QingYang disuse" is the basic pathogenesis of primary intracranial tumor, clinical around the basic pathogenesis,because the pathogenesis established treatment and the complex prescription.Treatment should be "to eliminate pathogenic factors before".(2) Professor Zhou thinks the pathological nature is much the root is empty and the surface is real,deficiency syndrome and empirical inclusion.The pathological factors of primary intracranial tumors give priority to "wind, phlegm, stasis, toxin", often and folders or composite.The disease mainly in the brain, with liver and kidney is closely related, involving heart, spleen and stomach, lung, often multi viscera disease.(3)Professor Zhou treating primary intracranial tumor common treatment is to dispel the wind phlegm,detoxicating and activating the collaterals,nourishing yin and tonifying the kidney,dissipating phlegm and dissipating phlegm,blood stasis,promoting blood circulation to remove blood,clearing away heat and toxin.The dispel the wind phlegm, detoxicating and activating the collaterals often choose:Batryticated silkworm, Scorpion, Centipede, Dew hive, Burdock,Earthworm.Nourishing yin and tonifying the kidney often choose:Caulis dendrobii,Radix asparagi,Ophiopogon japonicus,Fried turtle shell,Rehmannia,Rhizoma anemarrhenae,Eclipta alba,Glossy privet fruit,Fruit of Chinese wolfberry,Radices trichosanthis,figwort.The dissipating phlegm and dissipating phlegm often choose:Bile south star,Rhizoma typhonii,Rhizoma acori graminei,Rhizoma Pinellinae Praeparata,Seaweed,Concha ostreae,Selfheal.The blood stasis,promoting blood circulation to remove blood often choose:Ze Lan,Ligusticum wallichii,Ground beetle,Manis pentadactyla,Peach kernel,Leech,Cooked rhubarb,Caulis Spatholobi,Radix paeoniae rubra,Salvia miltiorrhiza.The clearing away heat and toxinoften choose:Mountain arrowhead, Ajugadecumbens, Barbed Skullcap herb, Blackend swallowwort root, Oldenlandia diffusa,Radix rhapontici.(4) Based on the above research results, to carry out medical case depth reading and medical interview and get Professor Zhou in the treatment of primary intracranial tumor basic recipe:Batryticated silkworm, Bile south star,Alisma,Ze Lan,Wartwort,Scorpion,13 kinds of herbs (not published);treatment is mainly by the basic prescription,with the pathogenesis of primary and secondary(22) or the main symptoms(5) of addition and subtraction.(5) In addition, the study also found that other experiences of Professor Zhou treating intracranial tumor:①Use of toxic drugs Maqianzi;②Accustomed to using insects drugs;③ Make good use of qianzheng powder;④For heat and blood stasis pathogenesis is good at using cold blood stasis four prescriptions;⑤For QingYang disuse pathogenesis, use the Rhizoma acori graminei;⑥Based on brain edema, reuse of Burdock.This study can be professor Zhou Zhongying pathogenesis as the core of the disease and syndrome combined with specific ideas and experience in treating primary intracranial tumors and to direct followers in clinical popularization and application, and the academic thoughts of Professor Zhou Zhongying treating primary intracranial tumor, on medical experience inheritance idea and method also has certain guiding significance.