Analysis Of Curative Effect Of Laparoscopic Sleeve Gastrectomy And Drug Therapy For Obese Patients With Type 2 Diabetes Mellitus

Objective:To evaluate the efficacy of laparoscopic sleeve gastrectomy and drug therapy in patients with type 2 diabetes mellitus(T2DM).Methods:With retrospective method,analysis in March 2014 to October 2017,the xinjiang uygur autonomous region people's hospital endocrinology,80 cases of drug therapy and minimally invasive,hernia and abdominal surgery 80 underwent laparoscopic sleeve gastrectomy for obese patients with type 2 diabetes patient data,followed up for 1 year(respectively 1,6,12 month follow-up),divided into LSG group(LSG,80 cases)and drug group(80 cases),drug treatment,observe and analyze the two groups of patients followed for each node weight index(Body mass index.BMI),the Excess body quality percentage reduction(Excess weight loss percentage,% EWL),glycosylated Hemoglobin(HbA1c)Hemoglobin A1 c,and Fasting glucose,Fasting plasma glucose,FPG),insulin resistance index(Homeostasis model assessment of insulin to hold the index,HOMA-IR)and related indicators.Results:75 cases(93.7%)in the LSG group and 72 cases(90%)in the drug group were followed up.No patients in the LSG group were transferred to laparotomy,and all patients successfully completed the operation under laparoscope.Each time node in the process of postoperative follow-up,patients with a body mass index(BMI),the excess body mass reduction percentage(EWL %),glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),insulin resistance index(HOMA IR)are declining,% EWL for 12months(83.3 + 22.9)%,BMI from preoperative 39.3 + /-3.5 to 26.8 + /-5.2,glycosylated hemoglobin(HbA1c)from(8.4 + 2.8)% of preoperative fell to(6.4 +2.0)%,FBG decreased from 11.6 2.8 mmol/L preoperatively to 7.0 3.5 mmol/L.In the druggroup,%EWL was(4.8 5.2)%,BMI decreased from 38.6 6.7 to 36.2 6.7,HbA1 c decreased from(8.9 3.4)% to(7.5 3.8)%,and FBG decreased from(11.7 3.7)mmol/L to(8.7 3.1)mmol/L.Weight loss and diabetes mellitus were significantly different between the two groups(P<0.05).Postoperative blood lipid metabolism indexes were also improved in different degrees.Conclusion:The short-term efficacy of LSG in treating obesity with type 2 diabetes is reliable,and its efficacy is better than that of drug treatment.The remission rate of diabetes after 12 months of follow-up was 75%,and no serious complications occurred during the follow-up.However,its long-term effects and long-term postoperative complications need to be further followed up and observed.