The Correlation Of Osteocalcin With Thyroid Function,Bone Density,and Lipid Metabolism In Hyperthyroidism Patients

Objective:This study explored the correlation between osteocalcin and thyroid function,bone mineral density,and lipid metabolism in hyperthyroidism patients.Explore the role of osteocalcin in bone metabolism,lipid metabolism,and regulation of thyroid function.Methods:Data of thyroid hormone function and related antibodies,parathyroid hormone,25-OH-D,OC,and central BMD,waist circumference(WC),body mass index(BMI),lipid as Total cholesterol(TC),et al were collected.Spearman rank correlation analysis and logistic regression analysis were analyzed for all data.Results: Serum osteocalcin levels were positively correlated with TT3,FT3,TT4,FT4,TRAb,and TGAb(r were 0.504,0.515,0.396,0.388,0.293,0.178,respectively,P<0.01);OC was negative correlation with TSH(r=-0.302,P<0.01);OC was negative related with BMD of Ward triangle and total hip bone density(r were-0.193,-0.248,respectively(P<0.05).OC was negative related with WC,BMI,LDL-C and Triglyceride(TG),(r were-0.155?-0.186?-0.223?-0.222,respectively(P<0.05);Logistic regression analysis showed FT3?ALP?TC and TG were the main influencing factors of serum osteocalcin(P<0.05);Vitamin D deficiency was 92.34% in hyperthyroid patients.Conclusion: Secreted by osteoblasts in high conversion,OC maybe mediate lipid metabolism,and reduce central BMD.It is very important to add vitamin D to keep skeletal and muscular health for hyperthyroid patients indeed.