Correlation Between Serum Osteocalcin Level And Glucose And Lipid Metabolism And Testosterone Level In Overweight And Obese Male Population

Background and Objective In the past 30 years,the prevalence of overweight and obesity has increased significantly in the world.According to the 2015 press conference on Chinese residents'chronic diseases and nutrition of Chinese residents report,the prevalence of overweight and obesity in Chinese adults is about 30%and 12%respectively,so the problem of overweight and obesity has become a serious public health challenge in China.Obesity is a chronic disease caused by the increase of fat reserve in the body,which is often accompanied by hyperinsulinemia,insulin resistance,dyslipidemia,low degree inflammatory state and abnormal secretion of sex hormone.It is an important risk factor for the occurrence and development of many chronic diseases,such as type 2 diabetes mellitus,cardiovascular and cerebrovascular diseases,some types of cancer,gonadal dysfunction and so on.Previous studies have found that testosterone is the key hormone in the pathological process of metabolic diseases such as obesity.Testosterone deficiency is related to energy imbalance and impaired regulation of blood glucose and lipids.Low testosterone level is one of the risk factors of obesity in men.The latest researches found that osteocalcin(OC)can act on pancreas,adipose tissue,muscle,testis and other organs as a endocrine hormone of bone,and is closely related to islet?cell proliferation,insulin secretion,blood glucose,blood lipid level and testosterone level.OC may play an active role in regulating body energy metabolism and androgen level,which points out a new direction for the early detection and treatment of male obesity.However,the data about the relationship between serum OC level and glycolipid metabolism and testosterone level in male overweight and obese patients are still very limited.This study provides a new diagnosis and treatment idea for overweight and obesity male by analyzing the relationship between the serum OC level and the related metabolic indexes and the serum testosterone level in male overweight and obesity patients.Methods 1.115 males,aged 40-60 years old,who were hospitalized in the physical examination center and cadre ward of our hospital from December 2017 to June 2019,were selected as the study objects.All subjects were divided into three groups according to body mass index(BMI).Subjects with BMI greater than or equal to 18.0kg/m~2and less than or equal to 23.9kg/m~2,greater than or equal to 24.0kg/m~2and less than or equal to 27.9kg/m~2,greater than or equal to 28 kg/m~2were included in the normal control group(40 cases),overweight group(40 cases)and obesity group(35 cases)respectively.General anthropometric data such as age,height,weight,blood pressure,waist circumference(WC)were collected.Fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),fasting insulin(Fins),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),triglyceride(TG),total testosterone and OC levels were collected.According to the formula,body mass index(BMI),homeostasis model assessment insulin resistance index(HOMA-IR)and homeostasis model assessment of?cell(HOMA-?)were calculated.2. By measuring the levels of serum OC,blood glucose,blood lipid and testosterone in the three groups of subjects,the correlation between OC and various metabolic indexes and testosterone level in obese and overweight people was explored,and the influence of OC on energy metabolism and obesity was further analyzed.The analysis of the data was completed by SPSS 18.0 statistical software.Results 1.The levels of BMI,WC,2h PG,FINS,TG and TC in obesity group were significantly higher than those in the other two groups(P<0.05);FPG,HOMA-IR and LDL-C in obesity group were significantly higher than those in the control group(P<0.05);there was no significant difference in age,blood pressure and HDL-C among the three groups(P>0.05).The levels of OC and testosterone in obese group were significantly lower than those in the other two groups(P<0.05),and the levels of OC and testosterone were decreasing in the control group,overweight group and obese group. 2. The results of univariate correlation analysis showed that OC was negatively correlated with BMI(r=-0.190,P=0.042),WC(r=-0.246,P=0.007),FPG(r=-0.191,P=0.035),2h PG(r=-0.126,P=0.017),TG(r=-0.125,P=0.033),HOMA-IR(r=-0.183,P=0.031),and positively correlated with testosterone(r=0.304,p=0.001)(P<0.05);In the control group,serum OC was negatively correlated with WC(r=-0.478,P=0.032)and HOMA-IR(r=-0.369,P=0.019)(P<0.05).3. The results of multiple stepwise regression analysis showed that WC,2h PG,HOMA-IR,TG and testosterone levels were the independent correlation factors of serum OC level in the overweight and obese patients(P<0.05).Conclusions 1.Compared with the control group,the level of serum OC and testosterone in the overweight and obese men decreased significantly,especially in the obese group.OC and testosterone may be protective factors of obesity. 2.In the male overweight and obese patients,the level of serum OC is negatively correlated with WC,2h PG,HOMA-IR and TG,and OC may directly affect obesity by regulating human energy metabolism. 3. In the male overweight and obese patients,the level of serum OC is positively correlated with the level of serum testosterone,which may indirectly affect obesity by positively regulating the level of testosterone.