A Clinical Study Of Jiawei Simiao San In Treatment Of IgA Nephropathy With Of Damp-heat Type

Objecttive: To observe the effect and safety of Jiawei Simiao San in the treatment of IgA nephropathy with damp-heat type,providing new ideas for the treatment of IgA nephropathy.Methods: Patients who met the inclusion criteria for IgA nephropathy were randomly assigned to the experimental group and the control group according to the random number table method.The control group took Huangkui capsule(5 tablets at a time,3 times a day)on the basis of Western medicine treatment,and the experimental group was treated with Jiawei Simiao San(200ml each time,sooner or later)on the basis of Western medicine treatment.The course of treatment is 12 weeks.To observe and recorde 24-hour urinary protein quantification,urine red blood cell count;serum creatinine,blood urea nitrogen,glomerular filtration rate,serum albumin and other indicators TCM syndrome scores and clinical efficacy evaluation before treatment,treatment 4 weeks,8 weeks of treatment,and 12 weeks of treatment.Result:?.Urine red blood cell count: After treatment,the urine red blood cell counts were significantly reduced in both groups.Compared with before treatment,the difference was statistically significant(P<0.01).The difference between the two groups was statistically significant(P<0.01).The test group was better than the control group.?.24-hour urinary protein quantification: After treatment,the 24-hour urinary protein decreased in both groups,compared with before treatment,the difference was statistically significant(P<0.01).There was a statistically significant difference between the two groups(P< 0.05),the test group was better than the control group.?.Serum albumin: After treatment,serum albumin levels increased in both groups,compared with before treatment,the difference was statistically significant(P<0.01).There was no statistical difference between the two groups(P>0.05).?.Renal function: After treatment,serum creatinine in the experimental group was lower than that before treatment(P<0.01).Compared with before treatment,there was no significant change in the control group(P>0.05).Compared with before treatment,there was no significant difference in urea nitrogen between the two groups(P>0.05).?.Syndrome scores of Chinese medicine: After treatment,the symptoms of the two groups improved significantly.Compared with before treatment,the difference was statistically significant(P<0.01).There was a statistically significant difference between the two groups(P<0.05).The test group was superior to the control group.?.Comparison of the curative effect of IgA nephropathy: After treatment,the total effective rate was 93.5% in the test group and 80.6% in the control group.The difference between the groups was statistically significant(P<0.05).The test group was better than the control group.?.Efficacy of TCM syndromes: The total effective rate was 93.6% in the experimental group and 83.9% in the control group after treatment.The difference was statistically significant(P<0.05).The experimental group was superior to the control group.Conclusion: Using Modified Si Miao San in treatment of IgA nephropathy with damp-heat type has a good effect,clinical symptoms and signs of patients can be improved,and the level of hematuria and proteinuria was reduced.