The Correlation Of Hyperhomocysteinemia With Serum Interleukin 6,Endothelin 1 And Nitric Oxide In Patients With Coronary Disease

Objective: to study the relationship between serum homocysteine(HCY)and interleukin 6(IL-6),endothelin 1(ET-1)and nitric oxide(NO)in patients with coronary heart disease(CHD),and to explore the mechanism of coronary heart disease induced by HCY.Methods: 160 cases diagnosed by coronary angiography in patients with coronary heart disease as experimental group,which combined with hyperhomocysteinemia in 64 cases of HHCY group,96 cases of normal homocysteine levels in non HHCY group,40 patients with coronary angiography negativein as control group.The serum levels of IL-6,ET-1 and NO were measured,and the differences among the groups were compared.Results:1.the incidence of HHCY in the CHD group was significantly higher than that in the control group(P < 0.05).2.There were differences in age,BMI,smoking,serum HCY,IL-6,NO and ET-1 between the HHCY group and the non HHCY group(P < 0.05).3.In HHCY group,HCY was positively correlated with IL-6 and ET-1,the correlation coefficients were 0.82 and 0.62,and HCY was negatively correlated with NO,and the correlation coefficient was-0.63;4.The incidence of ACS in group HHCY was significantly higher than that in non HHCY group(P < 0.001).Conclusion:1.Patients with coronary heart disease are prone to occur Hyperhomocysteinemia;2.Hyperhomocysteinemia is related to the clinical severity of coronary heart disease;3.Hyperhomocysteinemia may be involved in the pathogenesis of coronary heart disease by promoting the inflammatory reaction and further leading to the dysfunction of vascular endothelium.