The Relationship Between Hyperhomocysteinemia And The Severity Of Coronary Heart Disease Angina Pectoris

Research background Coronary heart disease is one of the most common heart diseases。In 2006 ,the development of Chinese health statistics show: Coronary heart disease is the third cause of death among urban residents,and the fourth cause of death among rural residents. At the same time,the incidence of coronary heart disease in China has shown a growth trend. Most of the risk factors of cardiovascular disease also showed a rapid continued upward trend. A large number of clinical and epidemiological datas indicate that hyperhomocysteinemia is a major factor leading to atherosclerosis and closely related to coronary heart disease. At present, although there are many researches on the relations of hyperhomocysteinemia and coronary heart disease at home and abroad,there are a small amount of studies on the relationship between hyperhomocysteinemia and the clinical severity of coronary heart disease. In China,the percutaneous coronary intervention in at least 50% of the hospitals is still in its infancy.In this study, we detect the homocysteine level of patients with angina pectoris,than analyse the results of different CCS classification, to clear the relationship between hyperhomocysteinemia and the clinical severity of coronary heart disease angina pectoris and provide a new basis for the prevention and treatment of coronary heart disease.Objective To discuss the relationship between hyperhomocysteinemia and the severity of coronary heart disease angina pectoris.Method The study group comprised 96 conseeutive patinets who are in Sino-Japanese Friendship Hospitall of Jilin University.47 of them are the patients of coronary heart disease angina pectoris. 20 of them aren't the patients of coronary heart disease Confirmed by some inspections. Exelusion criteria: Acute myocardial infarction within four weeks,coronary heart disease with angina pectoris have not attack within a month,left venrtieular ejection fraction<30%,valvular heart disease,recent operation and injury,renal or liver dysufnction,acute or chronic inflammation,acute leukemia,acute cerebrovasular disease,bronchial asthma,von Willebrand disease,cancer, oral viatmins,lack of estrogen,ogran transplantaton,self immunity disease. Group PacketGroup A: 26 patients of coronary heart disease angina pectoris whose CCS classification isⅠ-Ⅱ.Group B: 21 patients of coronary heart disease angina pectoris whose CCS classification isⅢ-ⅣGroup C: 20 patients who are not patients of coronary heart disease Age,sex,hypertension and smoking in every subjeets were recorded in detail.Blood sampling: Periphearl blood samples were taken before break in the next morning in hospitol.It need 5ml of periphearl blood samples to detect the lipid in the biochemical room and homocysteine in the central laboratory.Statistics analysis: SPSS13.0 Software Pack was used to make statistieal-analysis. All the numerical data was shown as mean±standard deviation and students t test was used to establish signifienace. Linear Correlation analysis was used to measure the coeffieient of correlation about the correlation data. We took P<0.05 as statistic significanee level.Results:1. The patients of coronary heart disease angina pectoris is higher than the patients who don't have coronary heart disease. The incidence of hyperhom- ocysteinemia in the patients of coronary heart disease are 62%,and in the patients who don't have coronary heart disease are 20%.Between the two groups there is a significant difference,and P<0.05.2.The homocysteine concentration of the patients of coronary heart disease angina pectoris whose CCS classification areⅢ-Ⅳis higher than whose CCS classification areⅠ-Ⅱ,and the homocysteine concentration of the patients of coronary heart disease angina pectoris whose CCS classification areⅠ-Ⅱis higher than the patients who don't have coronary heart disease. Between any two groups there is a significant difference,and P<0.05.3. The high homocysteine group is higher than the normal homocysteine group in the case of age and the proportion of men and smoking.4. Logistie-regression analysis indieates that Hcy,age,LDL and sexuality are the independent risk factors of coronary heart disease. And the order of the factors associated with coronary heart disease is sexuality >homocysteine>age>LDL. There's a strong relationship between the coronary heart disease and the homocysteine。It's the second important factor.Conclusion:1.The plasma homocysteine levels of patients with coronary heart disease are significantly increased,and there is a high incidence of hyperhomocy- steinemia in the patients with coronary heart disease。So it's necessary for the patients with coronary heart disease to test the homocysteine。2. Plasma homocysteine level and severity of angina pectoris is a positive correlation。3. Hyperhomocysteinemia is an independent risk factor for the coronary heart disease。4. Homocysteine has a greater influence than the traditional risk factors of the coronary heart disease and there's a strong relationship between the coronary heart disease and the homocysteine。5.Testing the homocysteine and correcting the hyperhomocysteinemia are the important measures which are helpful for the prevention and treatment of atherosclerosis。...