Effect Of Phacoemulsification On Corneal Endothelial Cells In Patients With High Myopia And Cataract

Objective To study the effect of phacoemulsification on corneal endothelial cells in patients with high myopia and cataract.METHODS Sixty inpatients with cataract were randomly selected from January 2017 to October 2017 in our hospital,including thirty patients with high myopia and cataract(high myopia group)and thirty age-related cataract patients(non-high myopia group).Cataract phacoemulsification combined with intraocular lens implantation was performed on patients.The coefficient of variation of corneal endothelial cells(CV),corneal endothelial cell density(CD),average area of corneal endothelial cells(AVG)and percentage of hexagonal cells(6A)were recorded before and 1 week,1 month and 3 months after surgery.The recorded data were analyzed.RESULTS There was no significant difference in CD and AVG between the high myopia group and the non-high myopia group(P>0.05).The high myopia group had larger CV and smaller 6A.The differences were statistically significant(P<0.05).The CV and AVG in one week,one month and three months after operation were significantly increased compared with that before operation(P<0.05).The CD and 6A were decreased compared with preoperative,and the difference was statistically significant(P<0.05).Moreover,by comparing between the two groups after operation,it shows that the CV and AVG in the high myopia group at 1 week,1 month and 3 months after operation were significantly higher than those in the non-high myopia group.Meanwhile,the CD and 6A were smaller in high myopia group.The differences were statistically significant(P<0.05).CONCLUSION Patients with high myopia and cataracts are less tolerant to corneal endothelial cells than those with age-related cataracts alone,and more susceptible to phacoemulsification surgery.The evaluation of corneal endothelial cells before operation and the protections of corneal endothelium in and after operation are the key to reduce complications and improve postoperative visual quality.