| Objective:To investigate the TCM constitution of Patients with diabetic foot(grade 0),find the distribution characteristics of their constitution,and f-urther analyze their suscePtible constitution;To observe the relationship between TCM constitution and clinical data of Patients with diabetic foot(grade 0),so as to Provide basis for individualized Prevention and tre at-ment of diabetic foot(grade 0)with TCM constitution theory.Methods:In this study,the method of cross-sectional survey was adoPted to investigate and study the Patients who met the inclusion criteria of diab-etic foot(grade 0)diagnosis inRuikang hosPital affiliated to guangxi university of traditional Chinese medicine from 2017-09 to 2018-11.The method of Professor qi's "classification and determination of constitutionin traditional Chinese medicine" was u-sed to determine the constituti-on of Patients.Combined with the gener-al information table,thedata o fPatients were collected in the form of qu-estionnaire.All the data were inPut into the Excel database,and SPSS 21.0 was used for statistical analysis.Results:1.General situation1.1 Of the 214 cases collected,115 were male,accounting for 53.74%.There were 99 female Patients,accounting for 46.26%.The mean age of the Patients was(53.25±11.58)years old,and the Peak age ofo-nset was over 45 years old,accounting for 77.1%.1.2 Distribution of diabetic foot(grade 0): damP-heat substance(21.03%)> Yin deficiency substance(19.16%)> qi deficiency substance(17.76%)> mild deficiency substance(15.42%)> Yang deficiency substa-nce(12.15%)> stasis substance(8.41%)> Phlegm-damPness substance(4.67%)> qi stagnation substance(0.93%)> sPecific quality(0.46%).1.3 The difference between gender and TCM constitution was statis-tically significant(P < 0.05).The constitution tyPe of female Patients was mainly Yin deficiency,accounting for 23.23%.The majority of men were hot and humid,accounting for 30.36%.1.4 The difference between age and TCM constitution was statistically significant(P < 0.05).Mild tyPe Patients were mainly distributed i-n the youth grouP.The Patients with damPness-heat and PhlegmdamPn-ess were mainly distributed in the middle-aged grouP.Patients with qi deficiency,Yin deficiency,Yang deficiency and blood stasis were mainly distributed in the elderly grouP.With the increase of age,the ProPort-ion of qi deficiency,Yin deficiency,Yang deficiency and blood stasis was on the rise,while the ProPortion of mild qi deficiency was on the decline.1.5 There was a statistically significant difference between body mass index(BMI)and TCM constitution(P < 0.05).Yin deficiency quali-ty and mild quality were more common in Patients with low body wei-ght.Normal weight grouP was more common in mild and stasis.Phleg-mdamPness and qi deficiency are more common in Patients with super recombination.Yang deficiency and qi deficiency are more common in obese Patients.1.6 The difference between TCSS and TCM constitution was statist-ically significant(P < 0.05),and TCSS was higher in Patients with Ph-legm damPness and blood stasis.1.7 The duration of diabetes in Patients ranged from more to less than 5 to 10 years,accounting for 34.60%.Over 10 years accounted fo-r 33.6%;Below 5 years accounted for 31.75%.After examination,the difference between the course of disease and TCM constitution and TCM constitution was statistically significant(P < 0.05).The duration of diabetes mellitus in Patients with hot and humid condition and mild typ-e is more than 5 years.The duration of diabetes in Patients with Yin deficiency,blood stasis and Phlegm damPness is usually 5-10 years.Th-e duration of diabetes in Patients with Yang deficiency and qi deficien-cy is more than 10 years.1.8 There was no statistical difference between smoking history,alc-ohol abuse history,family history of diabetes,complications and TCM constitution(P > 0.05).1.9 The distribution of syndromes in 214 Patients ranged from mor-e to less,including Phlegm and blood stasis syndrome(29.86%),liver and kidney deficiency syndrome(29.38%),Yin deficiency and blood sta-sis syndrome(22.75%),and qi deficiency and blood stasis syndrome(18.01%).The difference between TCM syndrome type and TCM constitu-tion was statistically significant(P < 0.05).The syndrome of qi deficie-ncyand blood stasis is more common in Patients with blood stasis and Yang deficiency.The syndrome of Phlegm and blood stasis blocking c-ollaterals is more common in Patients with mild and hot damPness.Yi-n deficiency and blood stasis syndrome is more common in Patients w-ith Yin deficiency and damPness and heat.Liver and kidney deficiency syndrome is more common in Patients with Yin deficiency and Yangdeficiency.2.Biochemical indexes and related examinations2.1 Glouse: FBG,2hPBG and TCM constitution showed statistically significant differences(P <0.05).Patients with Phlegm hygrosishave h-igher FBG.2hPBG was higher in Patients with heat and humidity.The-re was no statistical difference between HbA1 c and TCM constitution(P > 0.05).2.2 Blood lipid: there were statistically significant differences betwe-en total cholesterol(TC),triglycerides(TG),high-density liPoProtein ch-olesterol(HDL-C),low-density liPoProtein cholesterol(LDL-C)and TC-M constitution(P < 0.05).TC was higher in Patients with heat and humidity.The TG of Yin deficiency was lower and that of Yang deficiency was higher.Patients with Phlegm-damPness have lower HDL-C;Th-e Phlegm hyaloPlasm has higher LDL-C.2.3 Blood coagulation function: there was a statistically significant difference between fibrinogen(FIB)and TCM constitution(P < 0.05),a-nd Patients with hot and humid temPerament had higher FIB.2.4 Blood vessel color doPPler ultrasound results indicated that 13.74% of the Patients had no lower limb vascular lesions;45.97% of the Patients showed sclerosis.The number of Patients with Plaque accounte-d for 31.28%.Patients with stenosis accounted for 9.00%;Occlusion o-ccurred in 0% of Patients.After examination,it was suggested that the-re was a statistically significant difference between the lower limb vasc-ular ultrasound and TCM constitution(P < 0.05).The Patients without lower limb vascular disease were mostly found in damP-heat and Yang deficiency.Patients with sclerosis are more common in Yin deficiency,Phlegm and damPness;Patients with Plaques are mostly seen in qi def-iciency and blood stasis.Patients with stenosis are more common in qi deficiency and blood stasis.3.Correlation analysis of damP-heat quality,Yin deficiency quality and qi deficiency quality with various factorsLogistic regression analysis by binary classification indicated that h-eat and humidity were Positively correlated with TC,FIB,BMI and al-cohol abuse history(OR = 1.819,2.639,1.303,4.590).Yin deficiency was negatively correlated with BMI and TG(OR = 0.260,0.738).Qi d-eficiency and quality were Positively correlated with BMI,disease cour-s and age(OR = 1.295,4.320,2.751).Conclusion:1.Patients with diabetic foot(grade 0)are mainly middle-aged and elderly.2.The constitution of diabetic foot(grade 0)Patients is dominated by damP-heat,Yin deficiency and qi deficiency.3.The main syndromes of diabetic foot(grade 0)are Phlegm and blood stasis blocking collaterals and liver and kidney deficiency.4.High BMI,high FBG,low HDL-C and high LDL-C indicate Ph legm-damPness;High 2hPBG,high TC and high FIB indicate hot and humid quality;Alcohol abuse history,high BMI,high TC,and high FI-B are risk factors for hot and humid diabetic foot(grade 0);Age,cou-rse of disease,and high BMI are risk factors for qi-deficient diabetic f-oot(grade 0). |
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