The Clinical Efficacy Of Treatment For Warming And Dredge The Meridian In Treating Patients With Wagner Grade 0 Diabetic Foot

ObjectiveThis study aimed to observe warm the spleen and kidney meridians method deficiency, phlegm stasis cloud obstruction syndrome in patients with diabetic foot 0 clinical efficacy of the system to explore the pathogenesis and Modified Angelica Sini Decoction treatment mechanism.Methods80 cases of patients with diabetes foot 0 level in accordance with the principle of randomized, controlled divided into the treatment group and the observation group, both groups based therapy to diabetes. The treatment group based in western medicine treatment to take Modified Angelica Sini Decoction to western medicine group reduced square, a cobalt ammonium piece treatment, both groups continuous treatment for 6 weeks. Evaluation of two groups of integrated curative effect and main symptom scores change, Ankle brachial Index (observation Ankle brachial Index, ABI)-and emg, Fasting Blood Glucose (FBG),2-hr Glucose (P2hBG), Glycated Hemoglobin (HbAlc), Fasting insulin (FINS), Homeostasis Model Assessment of Insulin Resistance (Homa-ir), Total Cholesterol (TC), Triglycerides (TG), Low-density Lipoprotein (LDL), High-density Lipoprotein (HDL), C-reactive Protein (CRP), Fibrinogen (FIB) Index changes and three conventional, liver and kidney function monitoring such security Index.Results(1) ITT analysis showed that the total effective rate in treatment group total curative effect for 92.31%, the comparison group total effectiveness for 68.42%; PP analysis showed that the comprehensive effect, the total effective rate in treatment group and control group for 92.31% total effective rate of the treatment group were significantly 70.27%, better than control group (P<0.05).(2) After treatment, the two groups are improving TCM symptom scores (P < 0.05, P< 0.01), the treatment group improve more obvious; Treatment of TCM syndrome integral evaluation of the total effective rate of 94.87%, the comparison group total effectiveness for 70.26%, there were significant differences between contrast group (P<0.01); The treatment group after treatment is the main symptom scores group to have the varying degree improvement;(3) In the treatment group ABI improved significantly (P< 0.01), comparisons are between groups was significant difference (P< 0.01) group, the effect is not obvious (P>0.05).(4) After treatment, the two groups SNCV MNCV, which is before treatment improved significantly (P< 0.01), comparisons are between groups was significant difference (P< 0.01);(5) After treatment, the two groups were significantly P2hBG FBG, decrease (P<0.05, P<0.01), contrast between groups was significant difference FBG (P>0.05).(6) The two groups after treating FINS significantly (P<0.05, P<0.01), contrast between groups have significant difference (P< 0.01); The treatment group homa-ir significantly (P<0.01), but no significant difference compared with the control group (P>0.05).(8) The two groups after treating LDL levels drop, are obviously (P< 0.01), but no significant differences between groups contrast (P> 0.05). After treatment, the treatment group TC significantly, TG levels of HDL levels significantly increased (P<0.05, P<0.01), compared with controls TC, HDL levels improved significantly (P< 0.01);(9) After treatment, the two groups of FIB is before treatment, are obviously decline, (P<0.01), comparisons are between groups was significant difference (P<0.01);(10) Treatment group was obviously superior to improve liver and kidney function in control group (P<0.05), two groups of three conventional, indexes have no obvious (P> 0.05) change, both groups have no obvious adverse reactions.Conclusion(1) Spleen and kidney deficiency, two blood phlegmy wet occurs 0 level treasure-the resistance of diabetic foot the main pathogenesis;(2) According to the pathogenesis treatment appropriate to by the temperature, dredging for law;(3) By the temperature, dredging therapeutic method of reducing the angelica four inverse tonga square can improve patients with diabetes foot 0 level; the main clinical symptoms(4) Modified Angelica Sini Decoction square in can effectively improve peripheral vascular lesions;(5) Modified Angelica Sini Decoction square in nutrition nerve, improve the speed of the peripheral nerve conduction treatment group more advantages;(6) Modified Angelica Sini Decoction can improve blood sugar level, auxiliary control blood sugar fluctuations, improve insulin resistance, increase insulin sensitivity;(7) Modified Angelica Sini Decoction party of hematic fat have two-way adjustment function, the lowering of plasma fibrinogen level, thus improve microcirculation, prevent various thrombotic disease.(8) Modified Angelica Sini Decoction have a certain protective effect on renal function, safe and effective, no significant side effects, and it's worth popularizing.