| Objective Frontal lobe epilepsy(FLE)is a common epilepsy syndrome,which is characterized by nocturnal onset frequently.The sleep disorder is regard as a ubiquitous comorbidity to patients with epilepsy.Through recording and analysis of objective sleep structure parameters and subjective sleep-related scales in FLE,we studied the characteristics of sleep disorders in patients with FLE,furthermore,we studied the relationship between sleep disorders and degree of depression and fatigue.What's more,we tried to explore the factors accounted for sleep disorders in FLE so that we could find a way to improve the diagnosis and therapy of sleep disorders in FLE.Method 1.Eighteen FLE patients who came to Clinic of the Department of Neurology of Tianjin Medical University General Hospital were recruited to our study.15 healthy subjects who are matched in sex,age with FLE group were enrolled as control group.2.Every subject were asked to finish a sleep diary for 2 weeks.The FLE patients were required to provide epilepsy history and accomplish a seizures diary regarded as seizure frequency.3.All of the participants were evaluated by whole-night polysomnography(PSG)including the monitoring of sleep structure parameters,respiratory event,snore,oxygen saturation and others.The data monitored was analyzed by SPSS17.0.4.The subjects of 2 groups were also assessed by the subjective clinical scales after the PSG,including the Epworth sleepiness scale(ESS),the evaluation of fatigue scale(FS-14)scale,depression self-rating scale(BDI-II),Pittsburgh sleep quality index scale(PSQI).5.The relationship among subjective scales,objective sleep parameters and the clinical characteristics were reckoned by SPSS17.0 through Spearman correlation analysis.Result 1.Comparison of objective sleep parameters between 2 groups: the FLE demonstrated an obviously increase in total time in bed [(503.22±62.33)min vs(455.23±36.88)min,t=2.620,P<0.05],wake after sleep onset [(54.11±18.97)min vs(33.91±11.66)min,t=3.593,P<0.05],sleep stage shifts [(161.17±56.83)vs(111.13±24.37),t=3.169,P<0.05],sleep stage shifts per an hour [(22.6±6.25)vs(16.75±3.57),t=3.207,P<0.05],number of non-rapid eye movement(NREM)1 stage shifts [(42.56±15.26)vs(31.47±10.25),t=2.397,P<0.05] and NREM 2 stage shifts [(57.28±26.57)vs(40±12.27),t=2.316,P<0.05],wake stage[(25.33±10.97)vs(16.73±5.95),t=2.718,P<0.05] compared with controls.2.Comparison of clinical scales between 2 groups: FLE showed higher scores in depression [(9.33±5.01)vs(2.93±1.44),t= 5.163,P<0.05] and fatigue[(5.72±3.36)vs(2.87±1.06),t= 3.410,P<0.05] compared with controls.3.The correlation analysis among objective sleep parameters,subjective scales and clinical characteristics of FLE demonstrated sleep stage shifts was relative to,NREM 1 stage shifts,NREM 2 stage shifts,wake stage shifts and sleep stage shifts per an hour(r=0.777?0.685?0.553?0.796,P<0.05);while there was no correlation between wake after sleep onset and fatigue(r=0.050,P=0.844),wake after sleep onset was relative to depression(r=0.613,P=0.007);furthermore,the seizure frequency was relative to depressive scale(r=0.494,P=0.037)and sleep stage shifts(r=0.483,P=0.042).Conclusion 1.There are sleep disruptions persecuting the patients with FLE which are included the elongation of wake after sleep onset and total time in bed,the number of sleep stage shifts,sleep stage shifts per an hour,NREM 1 stage shifts,NREM 2 stage shifts,wake stage shifts.2.The degree of depression and fatigue in FLE is obviously decreased.3.The wake after sleep onset is related with depression,as well as,the seizure frequency is relative to fatigue and sleep stage shifts. |
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