Analysis Of Related Factors Of Progression Or Recurrence In Patients With Small Cell Lung Cancer

Objective:Small cell lung cancer has a high degree of malignancy,undergoes extensive metastasis and is very sensitive to initial radiation and chemotherapy,but is prone to relapse,and the prognosis has not been improved significantly over the years.In this review,we retrospectively analyzed various factors that can evaluate the progress of SCLC,and evaluated the progress of the disease in the treatment and during treatment interval,to formulate individualized treatment plans early.Methods:The clinical data of patients with small cell lung cancer diagnosed by pathology or cytology from the Department of Oncology,Shengjing Hospital,the Fourth Department of Oncology from January 2010 to December 2016 were collected.The corresponding serum sodium,potassium and calcium levels,CEA,NSE,D2 aggregates,white blood cells,platelets and other data and imaging data.Follow-up to January 2018,a total of 108 cases were collected.A total of 409 images were evaluated,of which 275 were in treatment and 134 were in treatment.During the treatment period,the disease progressed 45 times and the disease recurrence 56 times during the treatment interval period.Results:The disease progressed 45 times during the treatment period,and the serum NSE increased in 35 times(?2 = 54.141,P <0.001).The serum sodium level decreased 18 times(?2 = 74.858,P <0.001).Disease and disease imaging related to progress.Multivariate analysis showed that progression-independent risk factors were elevated serum NSE and decreased serum sodium,corresponding to risk of 7.819 and18.209,respectively.The disease progressed 56 times during the treatment interval,30 times had respiratory symptoms such as cough and dyspnea,?2 = 10.872,P = 0.001;48 cases had increased serum NSE,?2 = 16.060,P <0.001;I 2 = 13.478,P <0.001,indicating that respiratory symptoms,elevated serum NSE,and hyponatremia are associated with the progression of disease imaging.Multivariate analysis of the treatment interval showed that the independent risk factors for progression were respiratory symptoms,elevated serum NSE,and decreased serum sodium levels,corresponding to a risk of 3.430,7.392 and 18.495,respectively.The correlation analysis of the changes of serum NSE and serum sodium ion in the treatment period,r = 0.218,indicates a weak correlation between the two changes.Correlation analysis between the two treatment period,obtained r =-0.183,indicating a weak correlation between the two changes.Conclusion:Small cell lung cancer is highly malignant and sensitive to treatment.However,it is easy to relapse.When the time of imaging review doesn't reach,the prognosis of SCLC can be predicted by monitoring serum NSE and serum sodium.During the treatment interval period,the respiratory symptoms can be evaluated by reducing the interference of psychological factors,monitoring the serum NSE and serum sodium ion to evaluate the disease recurrence,discovering the changes of the disease as soon as possible,formulating the individualized treatment plan and prolonging the survival of patients.