The Association Of Hyponatremia With The Prognosis Of Patients With Small Cell Lung Cancer

Objective: To analyze the association of hyponatremia with the prognosis of patients with small lung cancer(SCLC).Methods: The clinical materials of 489 patients with SCLC treated in Zhe Jiang cancer hospital between January 2010 and December 2012 were retrospectively analyzed. Kaplan- Meier and Log-Rank test were used to analyze the data. Prognostic factors were analyzed by multivariate Cox proportional hazards model.Results: Hyponatremia occurred in 17.9%、13.3%、12.5% and 18.9% patients at 4 different clinical stages(before treatment, after 2 cycles of chemotherapy, after radiotherapy and after all the treatments). The serum sodium level was not significantly different among patients of different gender, age, BMI, KPS, hypertension and diabetes mellitus history, tumor stage, smoking history and tumor metastasis(P>0.05). Univariate analysis showed that hyponatremia significantly affected the survival of patients. Multivariate analysis showed that hyponatremia was the independent prognostic factor for SCLC. The relative risk of death of patients with hyponatremia was elevated by 1.297 times(95%CI:1.160~1.449,P<0.001), 1.366 times(95%CI:1.023~1.825,P=0.035), 1.770 times(95%CI:1.168~2.682,P=0.007) and 1.507 times(95%CI:1.167~1.944,P=0.002).Conclusion: Hyponatremia is an independent prognostic indicator for the survival of initially treated patients with small cell lung cancer(SCLC).