Relationship Between Carotid Artery Intima-media Thickness And Postural Hypotension And Related Risk Factors In Type 2 Diabetes Mellitus

Objective:In this study,the incidence of postural hypotension was analyzed in patients with type 2 diabetes mellitus with carotid intima-media thickness,in order to understand the correlation between postural hypotension and carotid intima-media thickness in type 2 diabetes.The effects of age,duration of diabetes mellitus,C-peptide(CP),glycosylated hemoglobin(Hb A1c),blood lipids,and other risk factors on carotid intima-media thickness were also analyzed in patients with type 2 diabetes mellitusMethods:A retrospective study of 293 inpatients with type 2 diabetes mellitus,according to carotid intima-media thicness(CIMT),the subjects were divided into 3 groups,CIMT <1.0mm,normal intima,echo evenly for the T1 group,1.0mm≤CIMT<1.5 mm,limitations of the intima thickening,echo enhancement,luminal rules for the T2 group,CIMT ≥1.5mm with or without calcified stenosis in the T3 group.To compare the incidence of hypotension hypotension among groups and the differences in age,sex,body mass index,diabetes duration,fasting C-peptide levels,Hb A1 c levels,and blood lipids between groups.Spearman correlation analysis method was used to study CIMT related influencing factors.The difference was statistically significant at P<0.05.Results:1.The overall incidence of postural hypotension was 32.76% in patients with type 2 diabetes mellitus.The incidence of postural hypotension was 18.18% in the T1 group(n=99),32.65% in the T2 group(n=98),and 47.91% in the T3 group(n=96).Incidence between the groups were statistically significant(P<0.05).2.The correlation analysis between CIMT and the influencing factor Spearman suggests that CIMT and age,diabetes duration,Hb A1 c level,total cholesterol(TC)level,triglyceride(TG)level,low density lipoprotein cholesterol(LDL-C)Levels and apolipoprotein B(Apo B)level were positively correlated(P<0.05),with fasting C-peptide(CP)levels,high density lipoprotein cholesterol(HDL-C)levels and apolipoprotein A1(ApoA1)levels were negatively correlated(P<0.05).Conclution:Postural hypotension has a relatively high prevalence among people with type 2 diabetes,and CIMT has an effect on it.With CIMT thickening,the risk of postural hypotension increases.The regulation of CIMT related risk factors can help prevent carotid artery-intima-media thickness,thereby reducing the risk of postural hypotension in patients with type 2 diabetes.