| Diabetes is the metabolic diseases as the main signs of high blood sugar in endocrine system,diabetes coronary heart disease and high blood pressure are known as a serious threat with a major chronic diseases to human health。Carotid intima-media thickness can be used to reflect the individual load of atherosclerosis extent,It is a powerful factor that can be used to predict cardiovascular and cerebrovascular diseases.Objective:In this article,the carotid intima-media thickness an early indicator as a response of atherosclerosis. It is observed that the changes in the type 2 diabetes and the correlations with the other metabolic indexes. According to the changes of the glucose, lipids, and pressure in three different states to study he relationship between the atherosclerosis and the ones.Materials and methods:(1)Subjects:Choose T2DM patients in the endocrinology department of our hospital from September 2009 to September 2010 as the research objects. All selected patients were checked the color Doppler ultrasonography in the examination room of our hospital. The subjects into two groups according to CIMT = 0.9mm:the group of CIMT>0.9mm have 93 patients ,male 54; female 39,average age(66.03±9.45)year and average duration(7.64±7.52)year; The group of CIMT<0.9mm have 76 patients, male 46; female 30. Average age(59.56±12.21)year and average duration(6.85±4.51) year.(2)Criteria of diagnosis:①Diagnosis of DM according to the standard China Diabetes Guide in 2007.②Diagnosis of EH according to the new diagnostic criteria of WHO in 1999.③Standard value of blood glucose, blood pressure and blood lipids: Blood glucose values- HbAI<6.5%; Blood pressure values- BP<130/80mmHg; Blood lipids values- TG<1.5mmol/L,HDL-C>1.1mmol/L,LDL-C < 3.0mmol/L. (3) Exclusion criteria: Suffering from liver and kidney dysfunction; Patients with various acute and chronic diseases; Various cancer patients; Other endocrine diseases patients and Taking hormone for a long-term. (4)Clinical data: the patients into the group all Measured: Age,FPG,2hPGHbA1c,BMI,TG,TC,HDL-C,LDL-C,SBP,DBP,UA,F-Ins,BUN,Cr. And recorded Duration of diabetes,Smoking history,History of drinking,History of hypertension,Family history of T2DM.(5)All the data were carried out using SPSS 17.0 statistical software. Data 4.1: Expressed by the parameters X±S,Taken TC,TG,HDL-c to the natural logarithm so that it becomes a normal distribution after then to satistical.The number of measurement data between the two groups were compared using independent t test.Data 4.2:Count data was used to compare between the X2 test.Data 4.3:Use the Carotid intima-media thickness as the dependent variable, the relevant index as independent variables to the Logistic regression analysis.Data 4.4: Four groups were compared using ANOVA process .Into the pairwise comparison between four groups use the Duncan multiple comparison.Results:Comparison between the two groups:(1)Age,BMI,SBP,2hPBG,LDL-C,UA,F-Ins,there are significant differences between the two groups. (2)we use the Carotid intima-media thickness as the dependent variable, the relevant index as independent variables to the Logistic regression analysis :Age,SBP,2hPBG,LDL-C,into the statistical equation respectively.From the above statistical analysis, we can be concluded: Age, SBP, 2hPG, LDL-C as an independent risk factor of carotid CAS. (3)We selected patients were divided into four groups according to the different metabolic status of blood glucose, blood pressure and lipid after then compared them,we can get the results,the different states of metabolic controled between patients with T2DM,Age,T2DM duration(P=0.011),BMI(P<0.001),SBP(P<0.001),LDL-c(P<0.001)(P<0.01 or P<0.05)were significantly different。But when the pairwise comparison between groups,only in the A group: Age and Carotid intima-media thickness have the significant different Compared with other groups.Conclusion:(1)Patients of the type 2 diabetes melli with age, systolic blood pressure, uric acid, low-density lipoprotein cholesterol, postprandial 2h plasma glucose, fasting insulin and other related indicators changes can affect the carotid artery - in the film thickness.(2)Age, systolic blood pressure, low-density lipoprotein cholesterol, postprandial 2h plasma glucose is the independent risk factors for CIMT. (3)In the Patients of the T2DM, When the blood pressure, blood glucose and lipid metabolism are controlled by the ideal levels ,Carotid artery intima-media thickness is less than only one or two group.(4)We must adjust the relationship between blood sugar, blood pressure,and lipid.Decreased blood glucose levels Stablely,Lower blood pressure firmly,Adjustment disorder of lipid metabolism,In order to delay the occurrence of type 2 diabetes within the carotid artery - medial thickening. Reduce the development of macrovascular complications in the type 2 diabetes and the occurrence of atherosclerosis.
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