To Observe The Clinical Curative Effect Of Yiaikang Capsule In The Treatment Of HIV/AIDS Lung Spleen Qi Deficiency And Of NF-?B Signaling Pathway

Objective:To observe the clinical efficacy of Yiaikang Capsule in the treatment of HIV/AIDS patients with deficiency of lung and spleen qi,and to observe the gene expression of NFKB1 and NFKB1 in the NF-?B signaling pathway,and to explore the HIV/AIDS lungs.Relationship between Expression of NFKBIA,NFKB1 and NF-?B Signal Pathway in Patients with Spleen-qi Deficiency Syndrome.Methods:In this study,20 patients with HIV/AIDS deficiency of lung and spleen were screened out from patients in Shangcai County,Henan Province,and 20 patients with HIV-infected patients with no evidence of TB were treated.Yiaikang Capsule combined with HAART Therapeutic treatment,HAART-free treatment was performed in the unrecognizable group for a period of 6 months.Before treatment,NFKBIA,NFKB1,immune parameters,viral load,and safety indicators were measured in the two groups of patients.After treatment,HIV/AIDS lungs were treated.The patients with spleen-qi deficiency group were tested for immune indicators,viral load and safety indicators,and clinical observation forms,TCM syndrome score tables,and quality of life scales were filled in.At the same time,20 healthy people in the same region were recruited as control groups for immunological indicators,NFKBIA,NFKB1,blood routine,liver and kidney function tests.Results:1.TCM syndrome efficacy:The total score of symptoms in HIV/AIDS patients with lung spleen-qi deficiency was significantly reduced after treatment.The total score of symptoms before treatment was 40.25±8.67,and the total score of symptoms after treatment was:11.80±8.80,and the difference was statistically significant(P<0.05).The effective rate was 90%,of which 18 cases were effective,2cases were stable,and 0 cases were ineffective.The frequency of symptoms appeared after the treatment of lung and spleen deficiency in HIV/AIDS group was reduced.Among them,asthma,cold,spontaneous perspiration,The scores of severe cold,loose stools,palpitation,palpitation,pale tongue,pale tongue,and white tongue were significantly reduced,and the difference was statistically significant(P<0.05).2.Quality of life:Statistical results on physiological,psychological,degree of independence,social relations,environment,and spiritual world show that there is a statistically significant difference in the pre-and post-treatment HIV/AIDS lung spleen-qi deficiency group(P<0.05).3.Immune Index:According to changes after CD4+T treatment,HIV/AIDS in the spleen-qi deficiency group was effective in 6 cases,stable in 8 cases,and invalid in 6cases.The statistical results of CD3~+,CD4~+,CD8~+,TH/TS,CD25~+/CD4~+,CD28~+/CD4~+,CD45RA~+/CD4~+,CD45RO~+/CD4~+,CD95~+/CD4~+,CD38~+/CD8~+,CD95~+/CD8~+groups showed HIV/AIDS lung spleen-qi deficiency group There was no significant difference between before and after treatment(P>0.05);the relative count of CD25~+/CD8~+T lymphocytes showed statistical difference between the two groups before and after treatment(P<0.05).4.Viral load:The results before and after treatment of HIV/AIDS lung spleen-qi deficiency group showed that there were 2 cases effective,15 cases stable,and 3 cases ineffective.5.In the NF-?B signaling pathway,NFKBIA and NFKB1:There was no significant difference in the expression of NFKBIA gene between the HIV/AIDS group and the healthy control group(P>0.05).The expression of NFKBIA was increased and the expression of NFKB1 in the HIV/AIDS lung spleen-qi deficiency group compared with the healthy control group.The difference was statistically significant(P<0.05).Compared with the healthy control group,the expression level of NFKBIA gene in HIV/AIDS unrecognizable group was significantly higher(P<0.05).6.Safety indicators:Blood routine:There was no statistically significant difference in the results of leukocyte,neutrophils,lymphocyte ratio,hemoglobin,red blood cell count,platelet HIV/AIDS lung spleen-qi deficiency group before and after treatment(P>0.05);Statistics of alanine aminotransferase counts showed that there was a statistically significant difference between the pre-treatment and post-treatment of HIV/AIDS lung spleen-qi deficiency group(P<0.05);the total protein,total bilirubin,urea nitrogen,and creatinine statistics showed HIV.There was no significant difference in the pre-treatment and post-treatment between the AIDS and spleen-qi deficiency groups(P>0.05).Conclusion:1.Yiaikang capsule can effectively improve the clinical symptoms of AIDS patients with lung and spleen-qi deficiency syndrome,especially in the movement of asthma,cold,spontaneous sweating,bad cold,loose stools,palpitation,palpitation,tongue fat,pale tongue,white tongue coating Significant effect.2.Yiaikang capsule can increase the number of lymphocytes in the T-lymphocyte subsets of infected persons,promote immune reconstitution,and complement the virus inhibitory effect of antiviral western medicines,and has a tendency to stabilize the viral load.3.Yiaikang Capsule can improve the quality of life of patients,and has influence in six aspects of patients physiology,psychology,independence,social relations,environment and spiritual world.4.The efficacy of Yiaikang capsule in the treatment of patients with lung and spleen qi deficiency of HIV/AIDS is significant,which may be related to the regulation of NFKB signaling pathway by NFKBIA and NFKB1.