| Objective:This study based AIDS related diarrhea patients suffering spleen kidney yang deficiency syndrome as its research objects.Evaluated the clinical efficacy of Xieli Kang capsule on AIDS diarrhea patients as well as its effects on inflammatory cytokines IL-17,IL-6,and conducted research on intervention therapy of Xieli Kang by means of randomized controlled methods.Methods:60 cases of AIDS diarrhea patients suffering spleen kidney yang deficiency were included in this study,and they are randomly divided into two groups:treatment group for Xieli Kang capsule and control group for smectite particles.Treatment lasted for 4 weeks,and follow-up was conducted weekly to record the information of the patient's main symptoms,secondary symptoms and tongue pulse,and observed the clinical symptom score changes of diarrhea before and after treatment.Meanwhile,peripheral blood before and after treatment was kept to test IL-17,IL-6 and other cytokines,and then evaluate the effects of Xieli Kang capsule on peripheral blood IL-17 related cytokines.Results:The study included 60 cases of AIDS diarrhea patients suffering spleen kidney yang deficiency,6 cases were lost during the treatment,among all cases there were 2 cases in the treatment group,and 4 cases in the control group,totally 54 people completed the test.The clinical effective rate was 66.7% for the treatment group and 43.3% for the control group respectively,and the difference between the two groups was statistically significant(P < 0.05).The score of the frequency of diarrhea symptom scores were decreased,and the treatment group was compared with t=2.321,P=0.024;comparision between groups reached F=3.372,P=0.041<0.05.IL-17 cytokines in peripheral blood of the treatment group was increased from(1361.43±1676.57)pg/ml before treatment to(1662.09±1964.34)pg/ml.The difference before and after treatment was statistically significant,and control group went down from(1097.50±1087.49)pg/ml before treatment to(794.19±727.54)pg/ml.Covariance analysis was used between the groups,and the difference was statistically significant between the two groups.For those patients in treatment group,IL-23 increased from(13.38±37.41)pg/ml to(99.09±113.13)pg/ml and IL-6 increased from(11.58±11.24)pg/ml to(66.10±41.12)pg/ml,the difference between groups was significant.IL-21 of treatment group was tested by means of paired samples Wilcoxon test,p=0.018 before and after treatment,and the difference was statistically significant.Conclusion:1.AIDS diarrhea patients suffering spleen kidney yang deficiency were infected with evil in the course of time,accompanied by cold and dampness,phlegm,blood stasis and other causes in the disease,and also pathogenesis change of weakened heat existed.2.AIDS diarrhea patients suffering spleen kidney yang deficiency were having high mean lymphocyte CD4+T but the incidence of diarrhea was not significantly reduced.3.The curative effect of Xieli Kang capsule in treatment of AIDS diarrhea concerning spleen kidney yang deficiency was better than that of Smecta particles in the reduction of stool frequency of diarrhea patients.4.Xieli Kang capsule can improve IL-17,IL-6,IL-23 level in AIDS patients' perpheral blood.Induce initial T cell differentiate into Th17 cells to promote the development and proliferation of Th17 cells and to mitigate the reaction of intestinal immune system to inflammation.AIDS patients with spleen kidney yang deficiency suffered low detection rate of IL-21,and Xieli Kang capsule can improve the IL-21 level in peripheral blood. |
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