| Objective:This study aimed to 1)investigate the vitamin D levels of children aged 0-6 years old in Suzhou,2)explore the association of 25(OH)D3 concentrations with eczema prevalence among infants aged 38-48 days.3)assess the effect of 25(OH)D3 levels on allergic diseases incidence among infants aged 0-12 months old.Methods:1.From September 2015 to September 2016,a total of 15010 children were recruited into our study from an unselected population taking a regular health examination at the Municipal Hospital of Suzhou.Blood sample from tip of finger were collected for detecting 25(OH)D3 concentrations.2.The relationship between eczema and vitamin D levels: a total of 567 infants aged 38-48 days(293 boys,51.68% and 274 girls 48.32%)were enrolled into our study from children taking regular medical examinations at Municipal Hospital of Suzhou for the first time.The scorad score method was used to evaluate eczema of infants and 25(OH)D3 concentrations were determined by the method mentioned above.Standard questionnaires were completed by their parents..3.A total of 50 infants aged 0-1 years were recruited from an unselected population taking long-term routine physical examination in Municipal Hospital of Suzhou,including 32 boys(64%)and 18 girls(36%).A questionnaire survey completed by parents was used to collect allergic diseases incidence in children.The levels of 25(OH)D3 were measured at 3 months and 8 months old,respectively.A telephone interview was conducted at 12 months old to understand the occurrence of allergic diseases(eczema,food allergies,wheezing,asthma,allergic rhinitis).Results:1.1)The mean level of 25(OH)D3 of 15010 children is(35.83 ± 13.23)ng/ml,and boys have higher 25(OH)D3 than girls(36.48 ± 13.25 ng/ml vs.35.11 ± 13.16 ng/ml,P < 0.001).2).The average values of 25(OH)D3 in children aged 0-3 M,3-6 M,6-12 M,12-36 M,36-48 M and ?48M old are(34.49 + 11.53)ng/ml,(41.15-13.86)ng/ml,(48.03 + 17.25)ng/ml,(46.12-17.69)ng/ml,(28.49-16.55)ng/ml and(42.28 + 17.59)ng/ml.25(OH)D3 levels differed significantly across six groups(P < 0.05),with the exception of the difference between ?48M and 3-6M group.3)Children were classified into 12 groups according to the month of measuring 25(OH)D3,25(OH)D3 levels detected in January,February,March,July and November showed no significant difference compared with that in August,while the difference of 25(OH)D3 measurements between any two other months are statistically significant(all P < 0.001).The serum 25(OH)D3 concentration was classified according to <10 ng/ml,10-20 ng/ml,20-30 ng/ml,and ?30ng/ml.The constituent ratio of serum 25(OH)D3 classification was significant different across 12 months(P<0.001).The proportion of children having 25(OH)D3 ?30ng/m L is less than 50% in January,March,November;The corresponding percentage ranges from 50% to 60 % in February,June,and December,and ranges from 60% to 70 % from July to September,while the percentage was above 70 % in April,May and Ocotber.2.567 infants were divided into four groups according to their scorad score: eczema scores<1,1?eczema scores <5,5?eczema scores<10,eczema scores?10,and the mean 25(OH)D3 level in each group were(29.09±7.48)ng/m L,(29.1±5.93)ng/m L,(28.18±5.77)ng/m L and(29.01±6.53)ng/m L.There was no significant difference between the four groups(P>0.05)?3.The 25(OH)D3 level at 8 months of age(55.04 ± 10.16 ng/ml)was significantly higher than that at 3 months of age(36.71 ± 12.29 ng/ml)(P<0.001).The average level of 25(OH)D3 at 3 months and at 8 months of age is(45.87±6.62)ng/ml.?There was no significant difference between boys and girls regarding 25(OH)D3 level at either 3 month old or 8 month old(P>0.05).There were 35 children(70%)reporting eczema during follow-up from 3 months old to 8 months old,and 25 children(50%)had food allergies.Frequent sneezing,runny noses and nasal congestion except colds occurred among 7 children(14%),and 8 children(16%)had dry eye itch and tearing.Only one child(2%)had wheezing,while 6 children were accompanied by dry cough(12 %).No child had asthma.There was no significant difference in the 25(OH)D3 level at 3 month age,8 month age,the change value,and average value of 25(OH)D3 between children with and without eczema(P>0.05).There was no significant difference(P>0.05)between children with and without food allergy regarding the 25(OH)D3 level at 3 month old,the change value and average value of 25(OH)D3.At 8 months of age,the 25(OH)D3 level was higher in children with food allergies compared with those without food allergies,but the difference was not statistically significant(P=0.075).There was no significant difference(P>0.05)in the 25(OH)D3 level at 3 months of age,change value and average value of 2(OH)D3 between children with and without sneezing,runny nose,and nasal congestion symptoms.At 8 months of age,symptomatic children had approximately 6 ng/ml higher 25(OH)D3 than asymptomatic children,but the difference was not statistically significant(P=0.071).Conclusions:1.The vitamin D level of children aged 0-6 years in Suzhou City was in good condition and 64.44% met sufficient requirements.However,in different gender and different age groups,children's vitamin D levels were not stable.2.There was no significant relationship between the occurrence and severity of eczema with vitamin D concentration in children aged 38-48 day.3.No significant association was observed between allergic diseases and vitamin D levels in children aged 0-1 years old. |
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