| Objective:To study the application of fresh Chinese medicine in ancient and modern literature,and to statistically analyze the application and characteristics of fresh Chinese medicine by using 230 prescriptions of 140 patients with essential hypertension treated by fresh Chinese medicine.Contents:The main research contents of this project include the study of the concepts and application categories of fresh Chinese medicine,the clinical application advantages of fresh Chinese medicine,the prospects for industrial development,and the analysis and study on the application characteristics of fresh Chinese medicine in the treatment of hypertension.Literature review:This paper mainly summarized the development of TCM study in the treatment of essential hypertension.The literature study found that essential hypertension can be classified as a syndrome of dizziness,headache,etc.according to its clinical manifestations.Such syndromes are richly discussed in ancient medical books.As a common and frequently-occurring disease in clinical practice,there has been an increase in the incidence of morbidity in recent years.TCM has certain advantages in the treatment of hypertension,not only in stabilizing blood pressure,but also in improving clinical symptoms,controlling and preventing complications.Through the etiology,pathogenesis,clinical and experimental research of hypertension,the in-depth interpretation of the mechanism of action of Chinese medicine can be beneficial to the further advancement and innovation of clinical and scientific research in the future.Research on the concept and application of fresh Chinese medicine:this paper combed the concept,application methods,approaches and indications of fresh Chinese medicine recorded in ancient Chinese medicine books.The study found that the application of fresh Chinese medicine was more often discussed in externally contracted fever and yin disease in ancient books.However,because of its definite curative effect,it was also involved in other medical miscellaneous diseases,bone-injured diseases,and women's and children's diseases.And not only for chronic diseases,but it was also applied in the treatment of a number of acute illnesses,indicating a wide range of applications of fresh Chinese medicine,which was highly praised by ancient physicians.The value of clinical application was worthy of recognition,and it also provided references for the clinical application of fresh Chinese medicine in the treatment of various syndromes.At present,there are no relevant literatures on the treatment of essential hypertension with fresh Chinese medicine through literature search.However,clinical observations have found that fresh Chinese medicine have obvious advantages in the treatment of hypertension.Modern Chinese medicine believes that syndromes of hypertension are mainly characterized by hyperactivity of liver yang,yin deficiency and internal heat,insufficient kidney essence,and the lesion is based on yin deficiency.Fresh Chinese medicine are rich in juice with strong nourishing effects.The treatment method of nourishing yin and clearing heat was recorded in numerous ancient books.These advantages match the pathogenesis of essential hypertension,ensuring the treatment effect.Through literature review,it has been found that the application of fresh Chinese medicine in the treatment and prevention of diseases has a long history in our country.In ancient books,it not only recorded the application methods of fresh Chinese medicine in the field of exogenous fever,indications and mechanisms of action,but also exerted therapeutic advantages even in many internal injuries,which also provided references for better observing and summering the range of application of fresh Chinese medicine.On the other hand,in-depth discussions were also counted on the active ingredients,pharmacological effects,and freshness preservation methods of fresh Chinese medicine,providing positive scientific evidence and guidance for upgrading and expanding the application and research of fresh Chinese medicine from the perspective of modern science and technology.Clinical application advantages and industrial development prospects of fresh Chinese medicine:Through literature review,the advantages of clinical treatment of fresh Chinese medicine were summarized and concluded.Combined with the current status of fresh Chinese medicine cultivation and regional economic development planning,the thinking of multi-channel development of fresh Chinese medicine cultivation was explored,as well as on the development model and ideas of modern Chinese medicine industry.The study believed that the clinical application and industrial development prospects of fresh Chinese medicine are broad.Apart from the reliable application of Chinese medicine in clinical practice,they also has certain advantages in increasing the national income and social benefits of the national agriculture,environment,medicated diet,increasing employment,stabilizing social services,and improving people's physical and mental health,and it has obvious features in clinical application,and it is worth further exploration and research.Analysis and research on the application characteristics of fresh Chinese medicine in the treatment of hypertension:"Traditional Chinese Medicine Inheritance Platform Software(V2.5)" was adopted to statistically process a total of 230 TCM prescriptions of 140 patients with essential hypertension treated by fresh Chinese medicine in the Outpatient TCM Department of Beijing Guangyang Bohai Hospital(Fresh Chinese medicine Base of Beijing University of Chinese Medicine)from July 2015 to July 2016.Based on the statistical results,the application characteristics and composition rules of fresh herbs in the treatment of essential hypertension were discussed.Methods:The personal information(such as name,gender,age,etc.)and clinical manifestations of outpatients meeting diagnostic criteria were recorded.With reference to relevant diagnostic criteria,previous illnesses were screened out,and a total of 140 patients meeting the above diagnostic criteria were selected.All cases were reviewed with reference to diagnostic criteria.Among them,103 were male patients,accounting for 73.57%of the total number of patients.There are 37 female patients,accounting for 26.43%of the total.The age was mainly distributed between 45 and 82 years old,with an average of 63.5 years old.This data was mainly compiled by the "Method of Collecting Chinese Herbal Medicine Names in Patient Prescriptions" in the Pharmacopoeia of the People's Republic of China(2015).A total of 230 prescriptions of enrolled 140 patients were analyzed statistically through data mining methods of frequency statistics,complex system entropy clustering,and unsupervised entropy hierarchical clustering integrated in the "Traditional Chinese Medicine Inheritance Platform Software(V2.5)" developed by China Academy of Chinese Medical Sciences,and association relationship,nature,flavor,channel tropism,composition and compatibility,as well as core Chinese medicine of the prescriptions were obtained,and the results were deeply analyzed by using TCM theories.The recognition of regularity was summarized to provide references for clinical application of fresh Chinese medicine in the prevention and treatment of hypertension.Results:Among the 230 effective prescriptions,the analysis through"Traditional Chinese Medicine Inheritance Platform Software(V2.5)" found that the four syndromes of fresh Chinese medicine in clinical treatment of hypertension were liver hyperactivity of liver yang(42%),yin deficiency and internal heat(38%),insufficient kidney essence(12%),and phlegm dampness obstructing the middle(8%)according to their frequency(from high to low).Through statistics,173 Chinese herbal medicines were finally collected.According to the frequency of occurrence of the Chinese medicine(from high to low),they were fresh Radix AchyranthisBidentatae,fresh Radix Puerariae Lobatae,fresh Radix Astragali,Fructus Arctii,fresh Radix Angelicae Sinensis,fresh Caulis Polygoni Multiflori,fresh Rhizoma Phragmitis,fresh stem and leaf of Radix Astragali.fresh Radix Trichosanthis,fresh Radix Rehmanniae Recens,fresh Fructus Perillae,fresh Herba Plantaginis,fresh Polygonum orientale Linn,fresh Herba Taraxaci,fresh stem and leaf of Cortex Eucommiae,fresh Herba Schizonepetae,fresh Herba Leonuri,fresh Rhizoma Dioscoreae,fresh Radix Paeoniae Alba,fresh Herba Agastachis,etc.The commonly used Chinese medicine in fresh Chinese herbal decoction were fresh adix Puerariae Lobatae,fresh Caulis Polygoni Multiflori,fresh Radix Astragali,fresh Radix Angelicae Sinensis,fresh Fructus Arctii,and fresh Radix Trichosanthis,with actions of nourishing yin and clearing heat,enriching and nourishing liver and kidney,activating blood and resolving stasis,which match syndromes of essential hypertension,and also reflecting the treatment principle of essential hypertension.Applying the association rule mining method,the number of support degrees was set as 33(indicating that the herb combination has at least 33 occurrences in the selected group),and the confidence level to 0.85.Finally,a total of 10 fresh Chinese medicine combination occurred in the form of pair of herbs,such as "fresh Caulis Polygoni Multiflori,fresh Radix Puerariae Lobatae","fresh Caulis Polygoni Multiflori,fresh Radix Astragali",and "fresh Caulis Polygoni Multiflori,fresh Radix Angelicae Sinensis",etc.Statistics showed that cold herbs were mostly used with frequency of 534,followed by 413 warm herbs,271 neutral herbs,110 cool herbs,with least 8 hot herbs.Through statistical analysis of five flavors of Chinese medicine,the highest frequency of occurrence was sweet herbs,which occurred 946 times,followed by 519 bitter herbs,498 acrid herbs,106 sour herbs,62 salty herbs and 13 astringent herbs.According to the statistical analysis of channel tropism,the final statistics were the most common in the frequency of entering to the liver channel,with a total of 610 occurrences,followed by 609 in the kidney channel,599 in the spleen channel,436 in the lung channel,418 in the stomach channel,290 in the heart channel,110 in the bladder channel,110 in the large intestine channel,65 in the gallbladder channel,12 in the small intestine channel,and 4 in the pericardium channel.Through the analysis and statistics of the inheritance platform,referring to the laws of the commonly used combination of fresh Chinese medicine,6 groups of core herbs combinations and 6 new prescriptions in the treatment of essential hypertension were counted.Conclusion:Based on the TCM prescription for hypertensive patients in Beijing Guangyang Bohai Hospital(Beijing University of Traditional Chinese Medicine Fresh Medicine Base),this project studied related prescriptions and similar herb combinations of fresh Chinese medicine in clinical treatment of hypertension.Through association rules analysis,and the entropy cluster analysis,the common herb combinations,common herb pairs and 6 new prescription combinations for treating essential hypertension were obtained.However,at present,it is concluded that the combination of new prescriptions is more concise,and the efficacy of clinical work and the mechanism of action for treatment need to be further explored.At the same time,research on efficacy evaluation and herb dosage is also the main summary in the future study.We must further exploration in the ingredients and efficacy of the geo-authentic crude herbs and planting herbs,and continue to accumulate and summarize the characteristics of fresh Chinese medicine in clinical work.In addition,this study found that fresh Chinese medicine in the treatment of essential hypertension is not only reflected in the role of blood pressure regulation and treatment,but also plays a certain advantage in stabilizing the disease and improving many clinical syndromes.At the same time,it also shows that fresh Chinese medicine is not only mentioned in many ancient books for the treatment of exogenous fever,but also worth exploring in the medical miscellaneous diseases,which needs expanded application. |
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