| Objective:By observing the clinical efficacy of Tongfutong combined with gabapentin in the treatment of patients with chronic daily headache and blood stasis,further investigation of chronic daily headache(CDH)to find a better treatment program.Methods:Collected in January 2013 in January 2018 by the Department of Traditional Chinese Medicine,Wuhan University People's Hospital diagnosed as 110 patients with primary daily headache.All patients were divided into control and treatment groups according to the random number table method.There were 55 patients in the control group and 55 patients in the treatment group.The control group received gabapentin capsules orally and the dose was taken according to instructions(three times a day,three capsules at a time).The treatment group used self-made Tongqiao Decoction(twice a day,each bag of 250ml water decoction)combined with gabapentin(three times a day,three at a time).Treatment for 2 weeks is a course of treatment.Both groups need continuous treatment for 4 courses,that is,8 weeks.During the treatment period,they should be strictly followed.Observe,record,and compare the following indicators:Before treatment,4 weeks of treatment,8 weeks of treatment,and 1 month after drug withdrawal,the symptoms of headache in patients with CDH,the proportion of traditional Chinese medicine syndromes and the proportion of each type were compared before treatment.Changes in total scores of TCM syndromes at the 4th week of treatment,8th week of treatment,and 1 month after drug withdrawal.Before and after treatment,4th week of treatment,8th week of treatment,and 1 month after drug withdrawal,Hamilton Anxiety Scale and Hamilton Depression Scale Such as the difference in the score.Results:1.Comparison of clinical curative effect:The total effective rate(90.00%)in the treatment group was significantly higher than that in the control group(66.00%)(?2=4.56,P<0.05).The difference was statistically significant.Both groups had effects on the four types of chronic daily headaches,and the treatment group was better treated with gabapentin combined with traditional Chinese medicine.Especially in the control of new daily persistent headaches,persistent lateral headache,the treatment group was significantly better than the control group,the difference was statistically significant(P<0.05).In the treatment of chronic tension-type headaches,we found that the two groups had comparable therapeutic efficacy.2.Comparison of Clinical Symptoms:By comparing the results of the two groups before treatment,4 weeks,8 weeks after treatment,and 1 month after drug withdrawal,we found that the patient's headache symptoms improved significantly,mainly in the duration of headaches,attack days The scores of headache,headache,and headache all decreased significantly,and the difference was statistically significant(P<0.05).In the treatment group,there was a significant improvement compared with the control group,which was mainly manifested in headache duration and degree of headache.The treatment group was significantly reduced,and the difference was statistically significant(P<0.05).3.VAS scores:The VAS scores of the treatment group and the control group were improved at the 4th week and the 8th week after treatment compared with before the treatment(P<0.05).At the 4th week of treatment,the VAS score decreased,indicating that the two groups had drug treatment.All have shown initial results.After 1 month withdrawal,the VAS score in the control group was higher than that in the 8th week(P<0.05).4.Concomitant symptoms:There was no significant difference in the scores of Hamilton Anxiety Scale and Hamilton Depression Scale between the two groups before treatment(P>0.05).Then we further observed the anxiety and depression status of the two groups after the 4th and 8th weeks of treatment,all improved,and the anxiety and depression improvement of the treatment group were better than the control group.After one month of withdrawal,the scores of Hamilton Anxiety Scale and Hamilton Depression Scale remained declining in both groups.5.TCM syndromes:Compared with the control group,the total effective rate of TCM syndromes in the treatment group was as high as 92%,which was 78%higher than that of the control group,and it was statistically significant(P<0.05).In the various types of chronic daily headaches,the total effective rates of new daily persistent headaches and persistent lateral headaches in the control group were 18%and 12%,respectively,whereas in the treatment group they were 30%and 18%,respectively.Statistically significant(P<0.05).Compared with the control group,the total effective rate of the treatment group was as high as 88%.Among the various types of CDH,the inefficiencies of chronic tension headache and persistent lateral headache in the control group were 4(40%)and 6(50%),respectively.After treatment,CTTH and HC inefficiencies were 1(11.11%),1(9.09%),the difference was statistically significant(P<0.05).6.Comparison of TCM syndrome scores:Compared with before treatment,the two groups showed a decrease in the 4th week after treatment,but it was more obvious in the 8th week.The control group and the treatment group saw the curative effect in the 4th week.The results were 12.56±0.42 and 12.31±0.28,respectively.The efficacy of the treatment group after 8 weeks of treatment(8.26±0.43)was significantly better than that of the control group(10.49±0.51).The difference was statistically significant(P<0.05).Follow-up at 1 month after treatment showed that there was no obvious recurrent episode of CDH in the treatment group after treatment withdrawal.The trend of TCM syndrome scores in the control group was 10.68±0.27,indicating that the efficacy of the control group was gradually losing efficacy,and the efficacy of the treatment group was still declining.It is 7.56±0.25.7.Adverse reactions:During treatment,there was 1 case of dizziness in the treatment group,1 case of mild dizziness,and 1 case of constipation in the control group.During the follow-up period of 1 month after treatment,both adverse reactions disappeared after half of drug withdrawal.No obvious abnormalities were found in routine biochemical tests,blood tests,electrocardiogram,etc.There was no statistically significant difference after treatment(P>0.05).The few adverse reactions that occur in the patient are initially considered as symptoms after taking gabapentin capsules.Although there are a few adverse reactions,self-made Tongfu Tang combined with gabapentin capsules and gabapentin capsules alone are still effective in treating headaches and have good safety.in conclusion:The use of self-made Tongfu Decoction combined with gabapentin capsules to treat chronic daily headaches was significantly better than the control group in improving the symptoms,duration,degree,and accompanying symptoms of the patients with headaches.The symptoms of TCM syndromes included headache,wrap,and sleep.Quality,food,tongue,and pulse can improve the quality of life of patients.The self-made Tongfu Tang combined with gabapentin capsule treatment group was significantly better than the control group with gabapentin capsule alone;self-made Tongfu Tang combined with gabapentin treatment of the disease,no adverse reactions,it is worthy of clinical promotion. |
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