| Objective:The aim of this study was to discuss the clinical efficacy and safety of the treatment of positive and negative blood petechiae to treat Parkinson's disease,to observe its for Parkinson's disease patients spirit,behavior,daily activity ability,the influence of movement function and treatment of complications.By comparing western medicine,it objectively evaluates the therapeutic effect and safety of fuzheng huayu granule in treating Parkinson's disease,to observe the centralizer blood particles syndromes curative effect of Parkinson's disease and its influence on serum Homocysteine(Homocysteine,Hcy),to provide the effective method of TCM intervention in Parkinson's disease to provide theoretical support and clinical evidence.Method:In the standard set of 78 cases of Parkinson's disease,take a random controlled study,divided into treatment group and control group,control group to dopamine silk hydrazine,pyrazole bei er,amantadine and other conventional western medicine treatment,the treatment group on the basis of conventional western medicine therapy combined with the centralizer blood particles,treatment period for 3 months.Respectively in the two groups before treatment,treatment after 1 month,2 months after treatment,3 months after treatment,using the unified Parkinson disease rating scale(unified Parkinson 's diseases,rating scale and UPDRS)evaluation of patients with each score.Using TCM syndrome quantitative scale score is used to evaluate the situation of TCM syndrome and TCM syndrome curative effect evaluation,and record the type of two groups of western medicine,dopamine equivalent dose(levodopa equivalent dosed,LED)and serum homocysteine levels.1.In the aspect of curative effect: The time effect difference was statistically significant(P<0.05)in the two groups after the treatment in January,after February,and after march.In the group effect analysis,there were statistically significant differences between the two groups in UPDRSI,UPDRSII,UPDRSIII,UPDRSIV and UPDRS(P<0.05).In comparison of the time and group interaction effects of the two groups,the scores and total scores of UPDRS were statistically significant(P<0.05).The scores of the two groups improved slightly after the treatment in January,and the improvement was the most significant after February,and the scores of all scores increased slowly after the treatment in March.The treatment group showed better symptoms after January and February,and the curative effect after February was slower than the control group.The efficacy evaluation of the two groups was compared,and the treatment group was ineffective in 3 cases,and 37 cases were effective.The total effective rate was92.5%.The control group was ineffective in 8 cases,28 cases were effective,and the total effective rate was 77.78%.The comparison between the two groups was statistically significant(P<0.05).2.Efficacy evaluation of TCM syndromes:Score in the group,the score of the treatment group after 3 months of treatment was decreased compared with that of the same group1 month after treatment and 2 months after treatment(P<0.05).the control group treatment score is slightly lower,there was no statistically significant difference(P>0.05);Score comparison between groups,two groups treatment after 1 month,2months,3 months after treatment scores were decreased,but the treatment group after treatment the score difference is more apparent in March,there was a significant statistical significance(P< 0.01).3.In LED,the equivalent dose of dopamine was reduced after 3 months in the treatment group,and the difference was statistically significant(P<0.05).The equivalent dose of dopamine in the control group increased after treatment,and the difference was not statistically significant(P>0.05).The comparison of dopamine equivalent dose after treatment showed statistically significant difference between the two groups(P<0.05).Result:4.Effects on homocysteine levels:There was significant difference in the level of homocysteine in the combined western medicine group with fuzheng chemical stasis(P<0.05).The lower levels of homocysteine in the control group were not significant,and the difference was not statistically significant(P>0.05).Compared with homocysteine levels after treatment,the difference was statistically significant(P<0.05).5.In the aspects of security:Two groups before and after treatment in patients with routine blood,liver,kidney,there were no statistical significance(P>0.05),2 groups of patients with routine urine,stool routine,and electrocardiogram(ecg)in both before and after treatment without exception,and in the process of treatment with no discomfort such as nausea,vomiting response,shows that the agent has good clinical safety.Conclusion:1.The treatment of patients with Parkinson's disease with the combination of fuzheng huayu granule combined with western medicine has an early effect on the improvement of patients' symptoms,and the long-term maintenance time is better than that of the conventional western medicine group.2.The centralizer blood particles combined western medicine therapy can effectively improve the patient's mental symptoms of Parkinson's disease,motor function and daily activity ability,reduce the complications,obviously improve the syndromes,reduce use western medicine.3.High level Hcy promotes the occurrence and development of Parkinson's disease,and promotes the level of serum homocysteine in the combined western drug of the fuzheng chemical stasis,and delays the progress of the disease.4.No adverse reaction event occurs during the treatment of Parkinson's disease,which is safe. |
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