To Study TCM Syndrome Elements And Their Distribution Law Ofthe Non-motor Symptoms In Wilson's Disease

Objective: Through a large sample of epidemiological investigations,the non-motor symptoms(NMS)of Wilson's disease(WD)were studied.Based on the clinical dialectical classification of Wilson's disease(WD),the correlation between non-motor symptoms(NMS)and TCM syndromes was summarized.The clinical guidance of clinical treatment of Wilson's disease(WD)with non-motor symptoms(NMS)provides a reliable basis for clinical treatment.?Methods:Based on the literature research,this paper designs "the non-motor symptoms(NMS)assessment scale of Wilson's disease(WD)",uses the epidemiological investigation method,collects the four diagnostic data and the associated non-motor symptoms(NMS)of patients with Wilson's disease(WD),establishes the relevant database,uses the frequency analysis and the card square test to carry on the statistical analysis,summarizes the distribution law of the non-motor symptoms(NMS)and TCM syndrome.The distribution law of each syndrome type and the correlation between each syndrome type and non-motor symptoms(NMS)were analyzed.Results:1.A total of 299 cases were collected,including 145 males and 154 females.The ratio of males to females was about 0.94:1.On average(24.26 + 9.56).There was no significant difference between the incidence and prevalence of WD in young people and adolescents.2.TCM syndrome type in hot and humid embodiment(74 cases,24.7%)are the most common,followed by alternating knot phlegm and blood stasis syndrome(61cases,20.4%),diseases with ease(58 cases,19.4%),liver and kidney Yin deficiency syndrome(58 cases,19.4%),spleen and kidney Yang deficiency syndrome(48 cases,16.1%).3.There was positive correlation between liver qi stagnation syndrome and depression(correlation coefficient =0.277),less food(correlation coefficient =0.255),and abdominal distension(correlation coefficient =0.167).Liver and kidney Yin deficiency syndrome and euphoric correlation coefficients(= 0.189),insomnia(correlation coefficient = 0.195),night sweats,correlation coefficients(= 0.702),sweat correlation coefficients(= 0.137),dry mouth(correlation coefficient = 0.187),lumbar acid(correlation coefficient = 0.34),tooth non-traumatic epistaxis(correlation coefficient = 0.171)have positive correlation;There was a positive correlation between spleen-kidney Yang deficiency syndrome and urine volume(correlation coefficient=0.238),edema(correlation coefficient =0.42),lumbago(correlation coefficient =0.27),and fatigue(correlation coefficient =0.25).Hot and humid embodiment and sweat(correlation coefficient = 0.28),salivate(correlation coefficient = 0.17),dizziness(correlation coefficient = 0.17),flustered correlation coefficients(= 0.15),constipation(correlation coefficient = 0.16),abdominal distension(correlation coefficient = 0.14),edema(correlation coefficient = 0.11),dry mouth(correlation coefficient = 0.18),bad breath(correlation coefficient = 0.39),itching(correlation coefficient = 0.23)have positive correlation;Each other by phlegm and blood stasis and loss of ability to calculate correlation coefficients(= 0.236),depending on the spatial disorders(correlation coefficient = 0.122),memory decline(correlation coefficient = 0.192),slow(correlation coefficient = 0.288),itching(correlation coefficient = 0.132),skin pigment deposition(correlation coefficient = 0.530)have positive correlation.4.There was a positive correlation between hyperhidrosis and the syndromes of liver-kidney yin deficiency and damp-heat internal syndrome.The correlation coefficient between hyperhidrosis and liver-kidney yin deficiency syndrome was 0.137(P=0.018),and the correlation coefficient between hyperhidrosis and damp heat syndrome was 0.28.(P<0.001);edema was positively correlated with spleen-kidney yang deficiency and damp-heat internal syndrome.The correlation coefficient between edema and spleen-kidney yang deficiency was 0.42(P<0.001),and the relationship between edema and damp-heat internal syndrome The coefficient was 0.11(P=0.049);skin pruritus was positively correlated with damp heat internal syndrome and sputum syndrome,and the correlation coefficient between skin itching and damp heat internal syndrome was 0.23(P<0.001),the skin itch knot with phlegm and blood stasis syndrome of correlation coefficient is 0.132(P = 0.023).Conclusion: Based on the clinical features and TCM syndromes analysis of 299 cases of non-motor symptoms(NMS)of Wilson's disease(WD)in this study,we conclude that:1.non-motor symptoms(NMS)of Wilson's disease(WD)were not related to sex or age.2.non-motor symptoms(NMS)of Wilson's disease(WD)is more common with hot and humid incontinence,followed by spasticity,liver qi stagnation syndrome,liver-kidney yin deficiency syndrome,and spleen-kidney yang deficiency syndrome.3.non-motor symptoms(NMS)of Wilson's disease(WD)is related to five types of TCM syndromes: dampness and heat syndrome patients common sweating,runny nose,dizziness,palpitation,constipation,abdominal distension,edema,dry mouth,bad breath,itchy skin,common feelings of patients with liver qi stagnation syndrome Low,eating less,abdominal distension,common emotional excitement,insomnia,night sweats,sweating,dry mouth,halitosis,backache,gums,and nasal discharge in patients with liver-kidney yin deficiency syndrome,and frequent urination,edema,and backache in patients with spleen-kidney yang deficiency.,fatigue,phlegm and blood stasis syndrome in patients with common computing power,visual space disorders,memory loss,unresponsive,itchy skin,skin pigmentation.4.Among the individual non-exercise symptoms and multiple types of syndromes,hyperhidrosis is more common in the damp heat ensemble syndrome than in the liver-kidney yin deficiency syndrome.Edema is more common in the spleen-kidney yang deficiency syndrome than in the dampness-heat ensemble syndrome.Itchy skin is More evidence is more common in damp heat syndromes.Clinical dialectical treatment on WD,therefore,should not only pay attention to motor symptoms and the relationship between TCM syndrome type,more should pay attention to the non-motor symptoms and TCM syndrome types,the relationship between the conclusion to the doctor of traditional Chinese medicine clinical diagnosis and treatment of the WD provides certain guiding significance.In clinical practice,it should be combined with the actual situation to grasp the individual differences of each patient,and extract the main factors of syndrome,and to make reference to the conclusion of this study.As the preliminary research,this study can be further expanded in the future research sample,improve the understanding of WD with the motor symptoms,for its research and clinical diagnosis and treatment of traditional Chinese medicine to provide solid foundation and a reliable basis.