Clinical Analysis Of The Expression Of ER,PR,p53,Ki-67,and Serum CA125 Levels In Endometrical Carcinomal

Objective:To investigate the correlation between the expression of estrogen receptor(ER),progestin receptor(PR),tumor suppressor gene p53,proliferating cell nuclear antigen Ki-67,serum CA125 levels and the clinical pathological features of endometrial cancinomal.Methods:82 cases,who was diagnosed as primary endometrial carcinoma by pathology and cytology during the first surgery in our hospital were collected.The clinical data of these82 patients were recorded in detail: including general condition,the results of preoperative fasting serum CA125 and postoperative pathological diagnosis(for example,endometrial cancer histological type,surgical pathology stage,histological grade,myometrial invasion depth and immunohistochemistry detection of endometrial cancinomal ER,PR,P53 and Ki67),as well as a statistical analysis.Results:1.82 cases of endometrial cancinomalr patients were in the age range of 30-76,the average age is 55.88±8.147,the age of onset is 50-59 years(46.34%).2.The positive rates of ER,PR,P53 and Ki67 in endometrial carcinoma were73.17%,75.61%,52.44% and 62.20% respectively.The positive rate of serum CA125 was 23.17%.3.Histological classification : The positive expression rate of ER,PR in the endometrioid adenocarcinoma group was significantly higher than that in the non-endometrioid adenocarcinoma group,The positive expression rate of p53,Ki-67 inthe non-endometrioid adenocarcinoma group was significantly higher than that in the endometrioid adenocarcinoma group,and the serum CA125 level was significantly higher between the two groups,The difference was not statistically significant.4.The pathological staging:The pathological staging was negatively correlated with the positive expression rate of ER and PR.The higher the pathological staging was,the lower the positive expression rate of ER and PR was.The positive expression of CA125 was positively correlated with the pathological stage.The higher the pathological staging was,the higher the positive expression of CA125 was.The positive expression rate of p53 and Ki-67 was significantly higher between the three groups,The difference was not statistically significant.5.The grade of tissue:The positive expression of ER and PR was negatively correlated with the grade of tissue.The higher the grade of ER and PR was,the lower the positive expression rate of ER and PR was.The positive expression rate of p53 and Ki-67 was positively correlated with the grade of tissue.The higher the grade of tissue was,the higher the positive expression rate of p53 and Ki-67 was.The positive expression of CA125 in the three groups was not statistically significant.6.The depth of myometrial invasion:The expression of ER,p53 in the depth of myometrial invasion was not statistically significant.The expression of PR,Ki-67 and CA125 was significantly different between the three groups.The positive expression of PR was negatively correlated with the depth of myometrial invasion,the depth of myometrial invasion was positively correlated with the positive expression of Ki-67,while there was no correlation between the expression of CA125 and the depth of myometrial invasion..Conclusion:1.Endometrioid adenocarcinoma showed high expression of ER and PR,while the specific pathological type of endometrial carcinoma showed high expression of p53 and Ki-67.2.The negative expression of ER and PR,and the overexpression of p53 and Ki-67,and elevated serum CA125 levels may be associated with the degree of malignancy of endometrial cancer.3.The detection of the expression of ER,PR,P53,Ki-67 combined with properative serum CA125 levels,is helpful to judge the degree of malignancy of endometrial carcinoma,thus developing an important theoretical basis on an individualized treatment to endometrial carcinoma patients.