Study On The Influence Factors Of The Prevalence And Incidence Of Cardiac Arrhythmia In Jinchang Cohort

Objectives To explore the prevalence and incidence of cardiac arrhythmia and to analyze the influence factors of these diseases and to estimate their incidence effects in Jinchang Cohort.And to explore the correlation between its outcome of sudden cardiac death and cardiac arrhythmia in the population,so as to provide a scientific basis for the prevention or treatment of cardiac arrhythmia and sudden cardiac death,and to provide basic data for a larger-scale epidemiological survey of this disease.Methods Baseline and follow-up data and cumulative mortality data of sudden cardiac death from2001 to 2013 were collected on Jinchang Cohort,using epidemiological surveys and physical and biological examinations and all-death investigation.A cross-sectional study analyzed the prevalence of cardiac arrhythmia to find possible influence factors.Logistic regression was used to study the relationship between cardiac arrhythmia and demographic characteristics,lifestyle behaviors,biochemical indicators,and underlying diseases.Relative risk(RR),attributable risk(AR),and attributable risk percentage(ARP)were used to test the possible influence factors that could affect the prevalence of cardiac arrhythmia in the cohort,and to estimate the incidence effects.A retrospective cohort study estimated cumulative mortality rate(CMR)of sudden cardiac death from 2001 to 2013,to analyze age trends of sudden cardiac death and the correlation both sudden cardiac death and cardiac arrhythmias.Results 1.The prevalence of cardiac arrhythmia was 20.17%in Jinchang Cohort,and significantly higher in males than females(22.51%vs 15.94%,respectively).The prevalence of cardiac arrhythmia was significantly different between different ages.There was a downward trend in ages below 45 years,with an 1 percent increase in age decreasing prevalence by 1.29%(linear regression equation y=67.04-1.29x).There was an upward trend in ages above 45 years,with an 1percent increase in age increasing prevalence by 0.72%(linear regression equation y=-22.36+0.72x).2.Multivariate logistic regression analysis showed that the risk factors for cardiac arrhythmia were sex,age,smoking,tea consumption,hypertension,coronary heart disease,and stroke in Jinchang Cohort.There were differences between males and females.Age,smoking,hypertension,and stroke were risk factors for males,while age and coronary heart disease were risk factors for females.Sex,occupation,smoking,tea consumption,and high level of calcium were influence factors for people under the age of 45 years after stratifying by age,while sex,education level,smoking,tea consumption,hypertension,coronary heart disease,and stroke were influence factors for people over the age of 45 years.3.Incidence effects estimation of cardiac arrhythmia could be related to gender,age,education,occupation,hypertension and coronary heart disease.Compared to people aged 45-54years old,people below and above that age group had much higher risk of cardiac arrhythmia incidence.For people aged less than 25 years and over 65 years,the RR of the disease was 6.28and 5.95,the AR was 3.06 and 2.87,and the ARP was 84.07%and 83.19%,respectively.Service personnel and workers had a higher risk of cardiac arrhythmias than cadres(RR=8.27 and 1.92,AR=5.16 and 0.65,and ARP=87.91%and 47.79%,respectively).Suffering from hypertension and coronary heart disease could increase the risk of cardiac arrhythmia(RR=2.43 and 2.63,AR=1.60 and 2.17,and ARP=58.82%and 62.00%,respectively).4.The 13 years CMR of sudden cardiac death,the final outcome of cardiac arrhythmia,was increasing trends with age,however,the 13 years CMR was lower under the age of 45 years,and it increased gradually over the age of 45 years.5.There were a negative correlation between the prevalence of cardiac arrhythmia and the 13years CMR of sudden cardiac death in ages below 45 years(r_s=-1.00,P<0.01),the result showed that there was no linear relationship between the 13 years CMR of sudden cardiac death as dependent variable and the prevalence of cardiac arrhythmia as independent variable(F=2.83,P>0.05),through nonlinear fitting both of them,nonlinear regression equation y=38.51-13.93ln(x-15.72)was set up.However,there was a positive correlation both of them in ages above 45 years(r_s=0.96,P<0.01),which showed there was linear relationship(F=18.57,P<0.01),and linear regression equation y=16.59+0.01x was set up.Conclusions 1.The prevalence of cardiac arrhythmia was closed to gender and age in Jinchang Cohort.It was higher among males than females.It declined with age less than 45 years,but increased after in ages above 45 years.2.For people less than 45 years old,the prevalence of cardiac arrhythmia was affected by workers occcupation,sex,smoking,tea consumption,and high level of calcium.For people older than 45 years old,the disease mainly concentrated in those who had lower education,and the influencing factors were sex,education,smoking,tea consumption,hypertension,coronary heart disease,and stroke.3.The incidence of cardiac arrhythmia was related to sex,age,education,occupation,hypertension,and coronary heart disease.We should design appropriate health interventions for high-risk groups according to those different factors.4.There was a negative correlation both the 13 years CMR of sudden cardiac death and the prevalence of cardiac arrhythmia,pointed that inducing sudden cardiac death probability was little with cardiac arrhythmia less than 45 years.Highly correlated between of them with age among people over the age of 45 years pointed out that these cardiac arrhythmias would be an important cause of sudden cardiac death.