Study On The Prevalence And Incidence Of Obesity,and The Relationship Between Obesity And Metabolism Disease Indexs In Jinchang Cohort

Objectives To investigate the prevalence and incidence of obesity and central obesity in Jinchang Cohort,analyze the relationship between the two obesities and metabolism disease indexes(4 lipid metabolic index,uric acid,blood pressure,and blood glucose),and provide scientific basis for the prevention and control of obesity and promotion of health in the cohort.Methods This study used data from a prospective study of Jinchang Cohort that was conducted at the Jinchuan Workers’Hospital in Jinchang city,Gansu province from June 2011 to September 2015.In this study,prevalence of obesity was calculated from the baseline data from 20,169 individuals(11,672 males and 8,497 females)with complete baseline,while incidence of obesity was calculated from follow-up data from those same individuals.The study consisted of a physical examination(including height,weight,waist circumference(WC),and other physiological indicators),blood and urine sampling(to test blood lipid,uric acid,blood pressure,blood glucose,and more),and epidemiological survey-interview(including demographics data,behaviors,occupational exposure history,and medical history)of47,010 past and present Jinchuan Group Co.,LTD employees(at baseline).In this study,prevalence of obesity was calculated from the baseline data from 20,169individuals(11,672 males and 8,497 females)with complete baseline and follow-up data,while incidence of obesity was calculated from follow-up data from those same individuals.Prevalence and incidence was calculated by stratifying different indicators.Obesity was determined using body mass index(BMI),and central obesity by WC.Results 1.The prevalence of obesity in the study was 11.62%.It increased with age,especially within the 50-59 years age group.By profession,it decreased from back office staff to workers to technical staff to cadres.The incidence of obesity in the study was 4.35%.It increased with age until peaking in the 30-39 years age group,after which it decreased with age.By profession,it decreased from workers to technical staff to cadres to back office staff.The prevalence and incidence of obesity was generally lower among women than men(2.89%vs 5.45%,and 10.16%vs12.68%,respectively),but among women approached that among men after 50 years of age and surpassed that among men after 60 years of age.The prevalence of central obesity in the study was 56.35%.It increased with age,especially within the 50-59years age group,until peaking in the 60-69 years age group,after which it decreased with age.It was lower among women than men(45.89%vs 63.97%),until among women surpassed that among men starting within the 60-69 year age group.By profession,it decreased from back office staff to technical staff to workers to cadres.The incidence of central obesity in the study was 29.69%.It was lower among women than men(22.86%vs 37.16%).It peaked in the 30-39 years age group among men and 60-69 years age group among women.By profession,it decreased from technical staff to workers to cadres to back office staff.2.BMI and WC were strongly correlated and had a dose-response relationship with the 4 lipid metabolic indexes.Within each BMI and WC group,women had higher rates of abnormal cholesterol and LDL-C and lower rates of abnormal triglyceride(TG)and HDL-C than men.The rate of abnormal cholesterol was 3.62times higher among women than men in the BMI≥28.0 kg/m~2 group.The rate of abnormal LDL-C was roughly 2 times higher among women than men in the WC≥100 cm group.The rate of abnormal triglyceride was 2.42 times higher among men than women in the 13.0 kg/m~2≤BMI<20.0 kg/m~2 group.The rate of abnormal HDL-C was 2.61 times higher among men than women in the WC≥100 cm group.3.Uric acid was strongly correlated and had a dose-response relationship with obesity and the 4 lipid metabolic indexes.Uric acid increased steadily with each lipid metabolic index.By gender,it increased most sharply right after the respective abnormal uric acid threshold.The rates of abnormal cholesterol and LDL-C by uric acid group were higher among women than men.That difference for abnormal cholesterol was highest in the 360 mmol/L≤uric acid<420 mmol/L group(it was3 times higher among women than men).The rates of abnormal LDL-C were 2 times higher among women than men in the 300 mmol/L≤uric acid<360 mmol/L group.The rate of abnormal TG was similar among the 2 genders.The rate of abnormal HDL-C was higher among men than women.It was 2.43 times higher among men than women in the 65 mmol/L≤uric acid<300 mmol/L group.4.Obesity,or BMI and WC,was directly related to abnormal blood pressure and abnormal blood glucose.The rate of abnormal blood pressure and abnormal blood glucose differed among the 2 genders more by WC stratification than BMI stratification.The rate of abnormal blood glucose among women increased faster after the WC threshold for central obesity.The rate of abnormal blood pressure in the 32.0kg/m~2≤BMI group was 9 times that in the 13.0 kg/m~2≤BMI<20.0 kg/m~2 group.The rate of abnormal blood pressure among women was 1.68 times higher than men in the 85 cm≤WC<90 cm group.The rate of abnormal blood glucose in the 100cm≤WC group was 5 times that in the 57 cm≤WC<75 cm group.The rate of abnormal blood glucose among women was twice that among men in the 90 cm≤WC<95 cm group.Conclusions 1.In this study,the prevalence of overweight was higher than the national average(36.13%vs 30.1%,respectively),prevalence of obesity was higher than the Gansu provincial average and similar to the national average,and prevalence of central obesity was higher than the national average.The incidence of overweight,obesity,and central obesity is high in this study.The prevalence and incidence of overweight,obesity,and central obesity is higher among men than women.As for the age of 30-39 age group,as for the gender of male,as for the profession of technical staff are the people at high risk of obesity.2.Using only BMI might not capture all obesity cases.Thus,we should use both BMI and WC for obesity management of large populations,and WC for more comprehensive and convenient obesity control of individuals,and WC should be considered for people with normal BMI.Compared with body mass index,waist circumference has more close relationship with the 4 lipid metabolism indexes.3.Obesity was associated with the 4 lipid metabolism indexes,uric acid was associated with obesity and the 4 lipid metabolism indexes,and obesity had a strong dose-response relationship with blood pressure and blood glucose.To decrease the burden of obesity,controlling uric acid and lipid metabolism indexes can reduce the incidence of obesity,and controlling BMI and WC can reduce the occurrence of metabolic diseases.