| ObjectiveBy comparing the situation of olive oil medicine and Oak spray improving the skin lesions symptoms of breast cancer patients with acute radiodermatitis,to evaluate the clinical efficacy and safety of olive oil medicine in treating radioactive dermatitis for breast cancer patients.To provide a new basis for clinical application of olive oil medicine preventing and treating the acute radioactive dermatitis,furthering enrich the application range of the external treatment of traditional chinese medicine.Methods68 cases of postoperative patients with breast cancer who appeared acute radioactive dermatitis were randomly divided into treatment group and control group,by using randomized controlled study design method.36 cases in treatment group,adopting the method of external spraying olive oil medicine treatment;32 cases in control group,using the method of external spraying Oak spray treatment.Efficacy and safety evaluation methods:?For the main symptoms such as pain,itch,and erythema of skin lesions,With two groups of patients relieving time first in pain,itch,erythema after the medication and the degree of patients' pain,itching,erythema,skin lesion in the treatment of 14 days to evaluate the curative effect.?For other appearing wet peeling,skin ulcers,necrosis lesion and so on,lesion area changes as the main curative effect evaluation index,and respectively to evaluate the lesion area of change in the treatment of the third day,7days,10days,14days.?Evaluation and compared of the DLQI score changes of two groups before and after treatment.? Evaluation the safety of the treatment,by monitoring the patients' routine blood,liver and kidney function and skin allergic reaction index in the process of treatment.Results1.Relief time first in pain,itch and erythema after treatmentAfter treatment,pain and erythema relief of the treatment group for the first time for an average of 78.93 ± 63.10 hours and 7.91 ±2.97 days respectively,itching relief for the first time of the median is 0.75 hours.For the control group,pain and erythema relief for the first time for an average of 7.91 ± 2.97 days and 10.31 ± 2.46 days,itching relief for the first time of the median is 72hours.Comparison between the two groups shows that the differences of the treatment group and control group were statistically significant(P<0.05),on relief time in pain,itch and erythema,and Olive oil medicine can obviously shorten the relief time in the patient's subjective feeling and erythema,compared with Oak sPray.2.Evaluating two groups of painscore,itch,erythema,ARD dividing,DLQI score and comprehensive curative effect,in the treatment of 14 days(1)(1)The 14th day of two groups,treatment group had 31 patients in pain,and the pain of the median value is 0.5 points that was lower than before,control group had 26 patients in pain,and the pain of the median value is 0.5 points that reduced one than before.Among them,the treatment group and control group were about 93.50%and 93.50%of patients with pain relief.comparison between the two groups,the treatment group and control group pain quartile respectively(0.00,1.00)and(0.00,0.50)points after treatment with significantly difference between them.(P<0.05)?The 14th day of two groups,itching observed in the treatment group with 33 patients and the control group with 29 cases with itching.Treatment group and control group were about 42.40%and 42.40%patients cured.?Treatment for 14 days,the treatment group and control group were respectively 35 cases and 32 cases of patients with erythema,and the treatment group and control group were about 97.1%and 96.9%of patients with erythema relief.?Treatment for 14 days,the treatment group and control group was of lesion grading were about 91.7%,91.7%patients with effective treatment.There was statistically significant difference in the painscore,itch,erythema,ARD dividing,DLQI score and comprehensive curative effect of each group(P<0.05),showing that the symptoms were obviously alleviate than before.there was no significant difference in itch,erythema?ARD dividing and comprehensive curative effect between the two groups(P>0.05),and both of them all have good curative effect in these respects.(2)The 14th day of two groups,the median scores of the DLQI of treatment group and control group were respectively is 3.0 and 2.0 points that both of them all reduced 3.0 points than before.Comparison between the two groups,to compare the difference of the two groups,the results show that treatment groups'DLQI score difference of the mean was 3.03 ± 1.08 points,the control mean DLQI score difference was 2.84±1.32 points.There was no significant difference in DLQI scores less between the two groups(P>0.05),and both of them all have good curative effect.3.The healing of skin lesions such as the wet peeling,skin ulcer,necrosis that can measure the sizeTwo groups of Patients resPectively evaluated the lesion area of change in the treatment of the third day,7days,10days,14days.Treatment group had 13 patients in skin lesion,and its average area(cm2)are respectively 20.42±13.49,15.77±14.40,8.38±14.85,6.77±13.88,in the treatment of the third day,7days,10days,14days.Control group had 13 patients in skin lesion,and its average area(cm2)are respectively 22.36±8.29.15.27±8.77?8.50±10.12?4.45±9.91 in the treatment of the third day,7days,10days,14days.Through the adoption of repetitive measure analysis of variance,compared within and between groups before and after the treatment.The results shows that:?Skin lesion area reduction had statistically significant difference in each group compared with before in the treatment of the third day,7days,10days,14days.(P<0.05)? There was no significant difference of skin lesion area reduction between the two groups(P>0.05).?Two groups of interaction effect test showing that there was no significant difference between two methods of treatment on the extent of the lesion area,if we evaluate the lesion area at different time points(P>0.05).Treatment results suggest two methods of treatment,in terms of promote healing of skin lesions 4.Safety assessmentAfter treatment,the overall granulocyte levels haven't changed much than before,there is no significantly abnormal in granulocyte and liver and kidney function,and there is no occurred as well as the obvious skin allergic reaction during the period of medication.Show that using olive oil medicine is safe before and after radiotherapy.Conclusion:Effection of the two methods of external using olive oil medicine and Oak spray that promote breast cancer postoperative radiotherapy to wet peeling,skin ulcer,necrosis lesion healing is the same;External using olive oil medicine can alleviate symptoms of pain,itch,erythema faster than Oak spray.Olive oil medicine is curative effect in painscore,itch,erythema,ARD dividing,DLQI score and comprehensive curative effect as well as Oak spray.But,olive oil medicine group was slightly inferior to the control group in the pain relief.there is no significantly abnormal in granulocyte and liver and kidney function,and there is no occurred as well as the obvious skin allergic reactionduring the period of medication.Compared with the traditional Oak spray,Olive oil medicine for external using not only is effective and safe for breast cancer,but also have obvious advantages in the aspect of pharmacoeconomics... |
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