| Radioactive skin destruction is a common complication in the radiotherapy of malignant tumor. If acute radiodermatitis, which occurs first, is not treated in time, the radioactive dermal ulcer or even chronic radiodermatitis may attack, which not only bring about pain to the patient but also influence the continuity of the treatment, lower local control rate and survival rate. Therefore it is an urgent priority to select an effective medicine.This paper is divided into three parts, that is, the literature review, experimental study and clinical research.The review part is to conclude the current nursing of acute radiodermatitis, situation of treatment and frequently used medicine, and to review the establishment of animal model for radioactive skin destruction.Clinical ResearchClinical curative effect research on Heijiang Dan in treating acute radiodermatitisObjective to investigate the clinical curative effect and safety of Heijiang Dan in treating acute radiodermatitis. Method During the same period, 30 patients who were treated with Heijiang Dan and 14 patients who were treated with biafine cream were collected; their treatment duration was 28 days and a follow-up was carried out to observe recovery rate and make a comparative study. Results The recovery rate of treating acute radiodermatitis with Heijiang Dan was 81.48%, and effective rate is 100%; for the biafine cream group, the recovery rate was 78.57% and effective rate is 100%. There was not significant difference (P>0.05). Conclusion Acute radiodermatitis in different stage could be effectively treated by Heijiang Dan.According the experimental study and clinical research mentioned above, the Heijiang Dan is notably effective in treating acute radiodermatitis and worth doing further development and research. Experimental StudyStudy On the curative effect of Heijiang Dan to the animal model for acute radiodermatitisObjective Form the perspective of cytobiology, the curative effect of Heijiang Dan to the rat who was irradiated by different dose was investigated. Method The animal model for acute radiodermatitis was set up by irradiating the female Wistar rat with Co60γ, 30 rats with 60Gy, 25 rats with 40Gy and 5 rats as the blank. The irradiated rats were subdivided into the Heijiang Dan group, the Ethacridine group and the control group. When the acute radiodermatitis occurred, Heijiang Dan and Ethacridine were applied respectively and the changes of skin destruction were observed. The rats were killed with IVC bled after 90 days feeding.The tissues in wound was placed in 10% neutral formaldehyde for fixation and embedded with paraffin,then skin wound was made into horizontalis sections with the depth of 5μm,and sections that have been stained with hematoxylin and eosin was observed under the microscope. Results With the same radiation dosage, the ulcer healing rate of medication group and Heijiang Dan group is higher than the control group and the Ethacridine group respectively (P>0.05). The healing rate of Heijiang Dan group irradiated by 60Gy is higher than the Heijiang Dan group irradiated by 40Gy. Under light microscope, referred with the blank and compared with the control group, the epithelium proliferated, the epidermis thickened and skin appendant organs such as hair follicle and sebaceous follicle grew in number, the fibroblast increased and the inflammatory cell infiltrated in the medication group irradiated by the same dose. Compared with the Ethacridine group, the healing situation of the Heijiang Dan group irradiated with the same dose was better. In the group treated with the same medicine, the healing situation of rats irradiated by 40Gy was better than those by 60Gy. Conclusion The Heijiang Dan can improve the healing of skin destruction caused by acute radiodermatitis. |
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