| Purpose:Evaluation of traditional Chinese medicine treatment of breast cancer lymphedema clinical research literature and quality of traditional Chinese medicine treatment of breast cancer lymphedema drug laws, its clinical efficacy and safety of a systematic evaluation, assessment of traditional Chinese medicine treatment of breast cancer lymphedema real effect, initially formed to support traditional Chinese medicine treatment of breast cancer lymphedema clinical evidence for the traditional Chinese medicine treatment of breast cancer lymphedema of efficacy and safety to provide evidence based medicine, provide a useful reference for clinical application.Material and method:Searchable database of literature: China Journal Full-text Database(CNKI), Chongqing VIP Chinese scientific and technical journals database(VIP), Wanfang Data(Wan Fang), retrieval time range: from 2006 to 2015. In the Chinese Journal Full-text Database(CNKI), the Chongqing VIP Chinese scientific and technical journals database(VIP), Wanfang Data(Wan Fang) database based on three search strategies developed in this study to search and screening of literature, the literature after screening Download and then manually classification, after classified documents in accordance with Carolina discharge standard in this study were screened again, this study literature 4238, after excluding repeated, review, personal experience, medical records and other documents included in the Document 62, the last to get in line with the present About 20 Chinese medicine treatment of breast cancer lymphedema literature studies. Of 20 studies data extraction, data available from traditional Chinese medicine treatment of breast cancer lymphedema herbal application rules and evaluation systems, and software and data via Review Manager5.3 GRADE profiler5 statistical analysis software to give Chinese medicine treatment of breast cancer surgery after lymphedema literature and quality evaluation of traditional Chinese medicine treatment of breast cancer lymphedema of drug laws, assess traditional Chinese medicine treatment of breast cancer lymphedema real effect, and the initial formation of traditional Chinese medicine treatment of breast cancer lymphedema clinicalevidence grades and recommendation strength.Results: 1. Chinese medicine treatment of lymphedema after breast cancer randomized clinical trial quality assessment Included in the study of literature in terms of whether the description to generate a random sequence, with only research 12,13,15,17,18 mentioned random sequence generation method, and the remaining 15 studies did not mention to generate random manner; for random assignment Hide results, only 18 of a research study to mention how to hide the results of random assignment; whether blinding researchers to participate in the study participated in the researchers explained 11,12,16,17,18 blinding way; Blinding evaluation results, most studies have mentioned single-blind or double-blind, only six research studies 6,9,10,13,14,19 did not specify the type of blinding; for incomplete results, selective reports and other offset three indicators, all research results did not appear incomplete, selective reporting and other offsets. Overall, the domestic literature in research of Chinese medicine treatment of breast cancer reported in the literature after lymphedema treatment is better, but there are some irregularities, we can not fully prepare reports in accordance with international standards. 2.Chinese medicine alone or in combination to treat breast cancer surgery lymphedema randomized clinical trials of efficacy evaluation Chinese medicine alone or in combination with conventional therapy compared to treating breast cancer lymphedema total efficiency difference was statistically significant [RR = 1.37,95% CI(1.29,1.45)], prompted Chinese medicine alone or in combination therapy more effective than the simple application of traditional treatment methods of conventional therapy. 3.This study included the application of traditional Chinese medicine, or in combination with other therapies to treat breast cancer lymphedema of 20 randomized controlled clinical study of the efficacy of the quality rating is HIGHT, this study gives evidence of the strength of recommendation is strongly recommended. 4. Chinese medicine for the treatment of breast cancer lymphedema more from spleen, reflecting the important role of the spleen in the body of water metabolism in the body.Statistics found that lymphedema after breast cancer treatment medicine is Wulingsan and Lingguizhugan soup based on based on different pathogenesis subtraction of the CD, the application of frequency in the top 10 of Chinese medicine are Astragalus(13times), Angelica(12times), licorice(11times), Gui(9times), Chuanxiong(9times), safflower(9times), mulberry(8times), Alisma(7times),Atractylodes(7times), Millettia(6times). Clinically, these traditional Chinese medicine is based on subtraction application, you can get a significant effect on breast cancer lymphedema treatment.Chinese medicine treatment of lymphedema after breast cancer randomized clinical trial quality assessmentConclusion: 1. At present, Chinese medicine treatment of breast cancer literature for lymphedema is not yet standardized literature reports, this study recommended CONSORT Group in 2010 published "CONSORT Statement 2010 edition" in the RCT randomized clinical trials reporting requirements specification writing reports. 2. The study found that the clinical efficacy of traditional Chinese medicine treatment of breast cancer surgery lymphedema exact, no adverse reactions reports and Chinese medicine, security is good, worthy of further research and clinical application. 3. The study of traditional Chinese medicine treatment of breast cancer after the current lymphedema GRADE rating HIGHT, this study gives evidence of the strength of recommendation is strongly recommended. Display of traditional Chinese medicine for the treatment of lymphedema after breast cancer has a high level of evidence, it is worth further study, provide valuable evidence for the formation of the standard form of Chinese medicine in the treatment of breast cancer lymphedema. 4. The study recommended treatment lymphedema after breast cancer operation can be applied to medicine Astragalus, angelica, licorice, Gui, safflower, mulberry, Alisma, Atractylodes basis in Wulingsan and Lingguizhugan soup, Alismataceae these traditional Chinese medicine, according to the diagnosis and treatment performed on the CD can play a significant clinical effect. |
PDF Full Text Request