Clinical Study About The Value Of NT-ProBNP In Traumatic Brain Injury

Objective:To investigate the relationship between N-terminal Pro-B-type natriuretic peptide(NT-pro BNP),intracranial pressure and hyponatremia in severe patients with isolated traumatic brain injury.Methods:We measured serum NT-pro BNP,ICP and serum sodium levels of 38 patients with isolated TBI on 2ed,12 th,24th,48 th and 72 ed hour after injury,who were admitted in the department of emergency and neurosurgery in our hospital from 2016 March to 2017 August.At the same time,10 healthy who have a medical examination were served as control group.The samples was dividied into two groups as high ICP Group [ICP>200mm H2O(1 mm H2O=0.0098 k Pa),n=24] and normal ICP Group(ICP<200 mm H2 O,n=14)based on mean ICP=200 mm H2 O,except 6 patient died within observation time.All patients were treated under the guidance of the Brain Trauma Foundation.The mean NT-Pro BNP values of all the observe time point in high ICP Group,normal ICP Group,and Control Group were progressed with Mann-Whitney U test to distinguish if there was statistical difference between groups.The mean NT-Pro BNP values of all the observe time point in high ICP Group were analyzed by Mann-Whitney U test to clarify the law of NT-Pro BNP with time.The same were completed in normal ICP Group.The relashion ship between NT-Pro BNP values and the corresponding ICP values in high ICP Group was analysised by spearman correlation analysis,if there is correlation,seeking correlation coefficient,so was in normal ICP Group.Results:1.The level of NT-Pro BNP in high ICP Group was significantly higher than it in normal ICP Group,P<0.05;2.In the high ICP Group,the level of NT-Pro BNP shown two incresed peak respectively at 12 ed and 24 th hour,P<0.05,and kept to 48 th hour,then begun to decrease at 72 ed hour,P<0.05;3.The relationship between NT-Pro BNP and ICP is positive linear correlation,?=0.659,P<0.05;4.Only one patient showed hyponatremia in normal ICP Group,and got improvement after symptomatic treatment,NT-Pro BNP was not associated with hydrological disorder after severe craniocerebral injury.Conclusion:Not all the rose of NT-Pro BNP in TBI is significanct,however,the level of NT-Pro BNP in high ICP Group is positive linear correlated with intracranial pressure and the level of ICP can be got indirected reflection through it.This study does not get the conclusion that NT-Pro BNP can be difined as a blood marker to predicted hyponatremia and distinguish CSWS from SIADH.