Clinical Research Of Sanxian Sijun Decoction In Treating Luteal Phase Inadequate Premenstrual Menstruation (Kidney Deficiency Syndrome)

Objective : To observe the clinical efficacy of Sanxian Tang Sijun Decoction in the treatment of early menstruation(deficiency of kidney)with luteal insufficiency,and provide evidence for clinical application.Materials and Methods: This research is based on the clinical investigation of Shi Sister's 2015-2017 period.After collecting the menstrual status questionnaires for the girls in four colleges and universities in Changsha,we selected those who meet the menstrual advance diagnosis and collected volunteers to come to our hospital for medical consultation.The Obstetrics and Gynecology Clinic of the First Hospital again conducted detailed dialectical examinations and included 64 patients with early kidney qi deficiency who were eligible for observation.Case collection time: From October 08,2016 to August 1,2017,randomized,positive drug parallel control design methods were used to randomly divide subjects into 32 cases in the treatment group and 32 cases in the control group.There was no significant difference in the age and course of disease between the subjects before treatment.The experimental group was treated with Sanxian Sijunzi Decoction,and the control group was given Jinkui Shenqi Pills.The medication was started on the 5th day of the menstrual period and was continuously taken for 14 days.A total of 3 cycles were used as a course of treatment.Observe the number of days ahead of the menstrual cycle before and after the experiment,the duration of the luteinizing phase,the HPS score of the basal body temperature,the serum progesterone(P)content of the BBT high-temperature phase5-8,the change of the TCM syndrome score,and the safety Changes in indicators,etc.,and observe whether there are adverse reactions in medication.Results:(1)Premenstrual clinical curative effect evaluation: There was a statistically significant difference between the two groups in the clinical curative effect(P<0.05),indicating that in the improvement of premenstrual clinical efficacy,the test group was superior to the control group.(2)The number of days ahead of menstruation: The difference between the two groupswas statistically significant(P<0.01).There was a statistically significant difference between the two groups(P<0.05),indicating that both groups can shorten menstrual advance time.However,the test group was superior to the control group.(3)Basal body temperature and high temperature phase maintenance days: The number of high-temperature phases in the two groups was longer than before,indicating that both groups could improve the basal body temperature of the subjects,and there was a statistically significant difference between the two groups(P<0.05).,indicating that the experimental group was superior to the control group.(4)Basal body temperature HPS scores: Both groups had higher HPS scores after treatment than before,indicating that both groups can improve the basal body temperature HPS scores of the subjects.The difference between groups was statistically significant(P<0.05).The test group was superior to the control group.(5)Serum progesterone(P)content of BBT high temperature phase 5-8: The average serum progesterone level after treatment was higher than before,indicating that both groups can improve the progesterone value of the subjects.There was no significant difference between groups(P>0.05),indicating that the efficacy of the experimental group and the control group were equivalent.(6)Total score of TCM clinical symptoms: After the treatment,the average total scores of the two groups decreased compared with that before treatment,indicating that both groups could relieve the TCM clinical symptoms of the subjects.The difference between the two groups was statistically significant(P<0.05).The test group was superior to the control group.Conclusion: Both experimental group and control group can regulate progesterone and improve luteal function,but the experimental group is better than the control group in improving the TCM syndrome,adjusting the menstrual cycle and the patient's basal body temperature.The treatment method is safe and effective,there is no obvious toxic and side effects,has a certain The clinical value.