Association Of The TTC39B Rs581080 Single Nucletide Polymorphism And Serum Lipid Levels And The Risk Of Coronary Artery Disease And Ischemic Stroke

Objective: Coronary artery disease(CAD)and stroke(IS)are both recognized as the leading cause of death and disability.The main pathophysiological mechanisms of these two diseases are atherosclerosis,while dyslipidemia is an independent risk factor.Studies have shown that TTC39 B rs581080 single nucleotide polymorphism(SNP)is associated with serum high density lipoprotein cholesterol(HDL-C)level.However,little is known about this association in Chinese population.In addition,the association between TTC39 B rs581080 SNP and CAD and IS has never been detected.Therefore,the aim of this study was to assess the association between TTC39 B rs581080 SNP and blood lipid levels and the risk of CAD and IS in Chinese population.Methods: In carrying out specific research work,the Han population living in Guangxi is divided into case group and control group to carry out specific research.There are 1741 patients with CAD(n = 578)and IS(n = 539)and 624 healthy subjects as the normal control group.A questionnaire survey was conducted to collect relevant clinical data and general data for different research objects,and the whole blood DNA was extracted from the subjects.Among the samples studied,TTC39 B rs581080 genotyping was comprehensively analyzed by means of Snapshot software system.Results: 1.The analysis showed that in the sample of the control group,the level of HDL-C of different genotypes of TTC39 B rs581080 was compared,and the results were P < 0.05,indicating that the contrast results had statistical significance,and the samples of the rs581080 G alleles and the non-G alleles were carried out by analysis.Compared with the sample,the HDL-C level is relatively low.2.It is concluded that the samples carrying the TTC39 B rs581080G allele have a certain correlation with the incidence of CAD,and the CAD risk of the rs581080 CG genotype: OR = 1.636,95%CI = 1.251-2.140,P = 0.000;CAD risk of the GG genotype: OR = 0.807,95%CI = 0.327-1.882,P = 0.641.3.Through the study,it is concluded that the samples carrying TTC39 B rs581080G allele have a certain correlation with the incidence of IS to a certain extent.Among them,the actual risk of IS in rs581080 CG genotype samples is OR = 1.596;95%CI = 1.214-2.098,P = 0.001;GG genotype IS risk: OR = 0.860,95%CI = 0.348-2.124,P = 0.743.After correcting the data related to the age,BMI,smoking,drinking,and hypertension of the sample,the corresponding genetic model is still shown in the rs581080 CG genotype sample,which is partly related to the incidence of CAD and IS(P < 0.05),indicating statistical significance.4.Stratified analysis showed an increased risk of CAD in subjects with the CG/GG genotypes,mainly in those who belonged to one of the following subgroups: males,age > 60 years,BMI > 24 kg/m2,hypertension,smokers and no-drinking.There was an increased risk of IS in subjects with the CG/GG genotypes,mainly in those who belonged to one of the following subgroups: males,age > 60 years,BMI > 24 kg/m2,hypertension and non-drinkers.The rs581080 SNP was also significantly interacted with hypertension on the risk of CAD and IS(P < 0.01 for each).Conclusion: TTC39 B rs581080 SNP has a significant correlation with serum HDL-C level,while rs581080 G allele carriers and rs581080 CC homozygous are relatively lower than the actual level of serum HDL-C.TTC39 B rs581080 single nucleotide polymorphisms have characteristics,also to a certain extent,and the life of the Han nationality population in Guangxi region there is a corresponding relationship of CAD and IS is seen,rs581080 CG genotypes of increased risk of CAD and IS.TTC39 B rs581080 SNP owned by the characteristics of the extent to which the patient's age,gender,smoking status,BMI,and hypertension,etc all have certain effect,make the life of the Han nationality in Guangxi region population incidence of CAD and IS increased or reduced.