Relationship Between Serum Uric Acid And Coronary Artery Lesions In Patients With Acute Myocardial Infarction

Objective: To explore the influence of the level of serum uric acid of acute myocardial infarction patients(AMI)to the degree of coronary artery.Methods In: From June 2015 to February 2017,we collected clinical data of 245 patients who diagnosed with acute myocardial infarction with parallel the percutaneous coronary intervention(PCI)in cardiology of the first affiliated hospital of Anhui Medical University.According to the clinical diagnosis of high uric acid standards,we divided patients into normal group(188 cases)and increased group of the serum uric acid(57 cases),and compared general clinical data between the two groups,and analyzed the correlation of serum uric acid level with the rang and degree of coronary artery of acute myocardial infarction patients.We analyzed the influencing factors of the degree of coronary artery lesions in patients with acute myocardial infarction by using multiple linear regression analysis.Results: There are statistically significant differences in hypertension prevalence,serum total cholesterol,triglyceride,low density lipo pro tein between the increased serum uric acid and normal group(P<0.05);The incidence of coronary slow flow in high serum uric acid group after percutaneous coronary intervention was 29.8%,which was higher than that in the normal group(10.1%)(P<0.05).The three groups of serum uric acid level is higher than coronary lesions coronary artery lesions with double and single group(P<0.05),and coronary artery lesions with double branch of serum uric acid level is higher than single group,(P<0.05).The results of correlation analysis show that high blood pressure,diabetes,serum total cholesterol,low density lipo pro tein,serum uric acid level is associated with gensini score(r respectively was 0.401?0.275?0.416?0.396?0.450,P<0.05);The results of multiple linear regression analysis show that the high blood pressure,low density lipo pro tein,serum uric acid level were the independence influencing factors for the degree of coronary artery of acute myocardial infarction patients(P<0.05).The multiple regression equation was: y(Gensini score)= 16.9 +0.14× hypertension +0.12× LDL-C(mmol/L)+ 0.42 ×serum uric acid(umol/L).Conclusion: There was correlation for serum uric acid level with degree of coronary artery of acute myocardial infarction patients.So the monitoring of serum uric acid level in patients with coronary artery disease had important clinical significance in assessing of the degree of coronary artery disease and preventing and treating for coronary heart disease.