| Objective: Our study is aimed at systematically evaluating and quantitatively analysising the prevalence of HPV infection in ovarian neoplasm tissue and the potential causal association between HPV and ovarian neoplasm,in order to provide evidence-based evidence for the prevention and treatment of ovarian cancer.Methods: The search terms included “human papillomavirus”?“HPV”?“ovarian tumor”?“ ovarian cancer”?“ovarian lesions ” in both Chinese and English,and “ ovarian carcinoma”?“ Ovarian Neoplasm”?“ovar*” in English.Chinese databases(CNKI,Wan fang,CBM and VIP)and English databases(PubMed,Cochrane Library,Embase,CNKI)were searched,the related magazines were also hand-searched.The extracted data included: study author,publication date,study area,histological origin,detection method,HPV type,sample size.The NOS was used to evaluate the quality of included case control studies,and the Meta-analysis was performed by Stata12.0.Results: The pooled prevalence of studies showed that 37.0%(95% confidence interval(CI): 29%,46%)of ovarian cancer patients were infected by HPV.Furthermore,the prevalence in Asian countries,European countries,and Africa respectively was 44.0%(95%CI: 2%,46%),5.1%(95%CI: 4%,7%),10%(95%CI: 4%,16%),in North America,where none of the tested ovarian cancer tissues were HPV-positive.The prevalence of HPV were 35.4%(95%CI: 31%,40%),15.2%(95%CI: 8%,22%),31.2%(95%CI: 29%,33%)in studies published from 1986 to 1995?1996 to 2005?2006 to 2017 respectively.With respect to tissue type,the prevalence of HPV examined by frozen tissue ?paraffin embedded tissue?fresh tissue respectively were 50.4%(95%CI: 41%,60%),12.1%(95%CI: 7%,17%),31.3%(95% CI: 29%,33%)respectively.The prevalence of HPV detected by PCR?ISH?IHC and Southern blot respectively were 24.8%(95%CI: 23%,27%),43.1%(95%CI: 39%,47%),34.9%(95% CI: 25%,45%),0%.2.Twenty-nine case-control studies were included,comparison between ovarian cancer?borderline ovarian tumor?benign ovarian tumor ?normal ovary of the HPV infection,the Meta-analysis showed that:(1)Compared with normal ovarian tissues,the infection rate of HPV in ovarian cancer was significantly higher and the difference was statistically significant[OR=6.24,95%CI(3.66,0.64),P=0.000];(2)Compared with ovarian benign tumors,the infection rate of HPV in ovarian cancer was significantly higher and the difference was statistically significant[OR=6.09,95%CI(3.46,10.71),P=0.000];(3)Compared with ovarian borderline tumors,the infection rate of ovarian cancer HPV increased,the difference was statistically significant[OR=1.33,95%CI(1.04,1.69),P=0.024];(4)Compared with normal ovarian tissues,the infection rate of HPV in borderline ovarian tumors increased,and the difference was statistically significant.[OR=3.85,95%CI(2.63,5.61),P=0.000];(5)Compared with benign ovarian tumors,the infection rate of HPV in ovarian borderline tumors was significantly higher and the difference was statistically significant[OR=6.30,95%CI(3.55,11.18),P=0.000](6)Compared with normal ovarian tissues,the infection rate of HPV in benign ovarian tumors increased,and the difference was statistically significant[OR=2.12,95%CI(1.16,3.86),P=0.014];Conclusions:(1)HPV was found in ovarian cancer tissues and the prevalence of ovarian cancer patients was 37.0%.However,the prevalence of ovarian cancer patients was different for different regions and publication date,and it was also related to detection methods and tissue type.(2)HPV infection may be a risk factor which is related to ovarian tumor.HPV infection was the initiating factor of ovarian tumor,or the immune deficiency of the ovarian tumor cell itself to make it susceptible to HPV.However,further research from larger studies is needed to verify this work. |
PDF Full Text Request