Meta-analysis Of The Relationship Between HPV Infection And Epithelial Ovarian Tumors

Purpose: This research aim at Meta-analysis the relationship between the HPV infection and ovarian epithelial tumors, in order to make clear the relations between them and provide evidence of evidence-based medicine.Methods: A comprehensive search of the CBM, CNKI, WANFANG DATA, VIP,Pub Med, FMRS was performed by computer for related literatures published from the established time of the datebases to the December of 2015. Included were case-control studies about HPV infection of epithelial ovarian tumors and normal ovaries. Related journals and references of the included literatures were searched by hand. All the literatures were imported to End Note, and two evaluators had screened, quality evaluated, date extracted, and cross checked according to a standard, when it had divergence, the two evaluators compromised settlement, or consulted the third evaluator.The meta-analysis was performed by Rev Man 5.3 and Stata12.Result: 17 case-control studies were included, all about 2044 patients, they were divided into 4 groups(normal ovary group, benign ovarian epithelial tumor group,borderline ovarian epithelial tumor group, malignant ovarian epithelial tumor group),two groups were case-control analysed every time, 6 times in totle. The heterogeneities of malignant ovarian epithelial tumor group VS normal ovary group and malignant ovarian epithelial tumor group VS benign ovarian epithelial tumor group were high, so the random effect model was used to analyse, the heterogeneities of rest 4 case – control were okay, so the fixed effect model was used to analyse. The results of the meta-analysis were as the follows: 1. The malignant ovarian epithelial tumor group had a higher HPV infection rate than the normal ovary group, the difference was statistically significant [P<0.0001, OR=8.64, 95%CI(3.32, 22.49)]; 2. The malignant ovarian epithelial tumor group had a higher HPV infection rate than the benign ovarian epithelial tumor group, the difference was statistically significant [P<0.00001, OR=8.64,95%CI(4.10, 18.20)]; 3. The malignant ovarian epithelial tumor group and the borderline ovarian epithelial tumor group had no obvious difference in HPV infection rate, there was no statistically significant difference [P=0.62>0.05, OR=1.12,95%CI(0.73, 1.71)]; 4. The borderline ovarian epithelial tumor group had a higher HPV infection rate than the normal ovary group, the difference was statistically significant[P<0.00001, OR=11.29, 95%CI(5.06, 25.22)]; 5. The borderline ovarian epithelial tumor group had a higher HPV infection rate than the benign ovarian epithelial tumor group, the difference was statistically significant [ P<0.00001, OR=11.01, 95%CI(5.17,23.45)]; 6. The benign ovarian epithelial tumor group had a higher HPV infection rate than the normal ovary group, the difference was statistically significant [ P=0.01,OR=2.44, 95%CI(1.22, 4.87)].Conclusion : HPV infection is much likely to play a role in the pathogenesis of epithelial ovarian tumors.