| Phthalocyanine?Pc?is a type of molecular dye with 18?electronic structure,which has the advantages of long absorption wavelength,high extinction coefficient and excellent photochemical characteristics.However,its poor water solubility and easy aggregation limit its application in biomedicine to a great extent.Nanomaterials are favored by researchers because of their controllable size and morphology.By introducing ions into the central ring of phthalocyanine,and thus changing the surrounding substituent groups to modify or assemble phthalocyanine to obtain nanostructures,it should be more suitable for biomedical applications.Phthalocyanine-based nanomaterials overcomes many shortcomings of traditional treatment methods and should has more future development potential.In this thesis,two nanomaterials based on phthalocyanine derivatives were synthesized and their applications in PTT and PDT were studied.In the first part,an HSA-assisted and molecular phosphorus phthalocyanine?P-Pc?-based nanoagent was reported.The nanoscale P-Pc-HSA obtained by the self-assembly method shows effective NIR-II absorption,long-term stability,good biocompatibility,low dark toxicity,and excellent photothermal conversion efficiency?64.7%?.In addition,P-Pc-HSA can be effectively taken up by tumor cells,and shows outstanding anti-tumor ability under NIR-II laser in vitro and in vivo.In the second part,nano-COF?LZU-1?was synthesized by solvothermal method.LZU-1-Si-Pc nanoparticles were successfully synthesized through the Schiff condensation reaction between the naked-CHO of LZU-1 and Si-Pc axial substitution group-NH2.The obtained nanoparticles have uniform distribution,good chemical and colloidal stability,negligible dark toxicity,and excellent in vitro phototoxicity.And we look forward to further application in vivo treatment.These studies will offer the possibility for the further development of nanomaterials based on phthalocyanine and phthalocyanine derivatives in the field of phototherapy. |
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