Synthesis Of CuMo₂S₃ Multifunctional Nanomaterials And Its Application In Photothermal/Photodynamic Therapy

In recent years,the incidence of cancer has increased year by year.So far,there is still no drug or means to completely cure cancer.Commonly used methods for treating cancer in the clinic include chemotherapy(drug therapy),surgery and radiation therapy.The emerging treatments include gene therapy,hormone therapy,immunotherapy,photodynamic therapy(PDT),and photothermal therapy(PTT).These emerging treatments are still in the research and development stage and cannot be actually used for clinical treatment.In order to achieve the desired therapeutic effect,chemotherapy(drug treatment)requires multiple administrations to the patient,resulting in drug resistance,reduced therapeutic effects,and toxic side effects.Although the surgical treatment does not produce systemic toxic side effects compared with chemotherapy,but the trauma is large,the wound healing of the patient is slow,and it is difficult to completely remove the tumor,which is likely to cause tumor recurrence and spread.Radiotherapy and surgical treatment are local methods for treating tumors.They use radiation to directly irradiate tumor sites and have strong penetrability,but radiotherapy can also damage or even kill normal cells.For these reasons,the development of new treatments for cancer has become increasingly important.PTT has been widely concerned due to its advantages of minimally invasive,non-toxic,and good cancer treatment.Cu S has excellent photothermal conversion capability and is one of the most studied photothermal materials.Various morphological Cu S nanomaterials have been developed by researchers,such as nanoflowers,nanodots,nanospheres and quantum dots.In cancer therapy,since PDT is a less invasive technique,its photodynamic effect can locally act on the tumor area,so that surrounding healthy tissues and cells are not damaged,so it has become an important preclinical study.Dihydrophenanthene e6(Ce6)is a commonly used photodynamic reagent in clinical practice.It has excellent photodynamic effects under the excitation of a specific wavelength source,but it does not have photothermal treatment effect.So we hope to prepare a material that combines these two therapeutic functions.Ternary metal sulfide(CuMo₂S₃)is a material composed of non-metallic sulfur and metal elements.It has been systematically studied and found to be used in photothermal therapy.Under the illumination of 808 nm laser,the aqueous solution of CuMo₂S₃nanoparticles shows a rapid heating effect,which can kill the tumor tissue at a certain temperature without causing obvious damage to the surrounding normal tissue.This is because the CuMo₂S₃ nanoparticles are in the near-infrared region.Have a strong absorption.At the same time,under laser irradiation,the surrounding oxygen molecules can receive the energy generated by the CuMo₂S₃ nanoparticles and convert to produce cytotoxic reactive oxygen species(ROS).In this paper,the CuMo₂S₃ ternary chalcogenide nanomaterial with integrated PTT/PDT function is synthesized by a simple and easy-to-use raw material,which has a small cytotoxicity.Good biocompatibility,while triggering synergistic treatment of PTT and PDT.In cell experiments,we found that the combination of PTT and PDT has a better therapeutic effect than PTT or PDT alone.At this stage,nanomaterials integrating multiple imaging modes and therapeutic methods have become a research hotspot.Therefore,we have prepared PEG-CuMo₂S₃-Gd nanocomposites,which have good biocompatibility and MR imaging capabilities.Through the in vitro and in vivo photothermal test of PEG-CuMo₂S₃-Gd nanocomposites,and the preliminary investigation of the imaging and photothermal/photodynamics of the materials,the results show that the nanomaterials are a combination of MR imaging and multiple treatments.New nanomaterials will have potential application value in the diagnosis and treatment of cancer.