Meta-analysis Of The Correlation Between C-Met Gene Expression And Prognosis In Patients With Solid Tumors

Cancer is a type of disease that has a very high mortality rate and usually presents as a malignant tumor.In view of this,many scientists are committed to early detection of biomarkers related to treatment and prognosis in order to improve the survival level of cancer patients.The c-Met gene is expressed in a variety of normal epithelial tissues,and in a variety of malignant Overexpression in tumors.However,how the overexpression of c-Met genes affects the prognosis of many types of cancer,and what kind of relationship exists between it and specific clinical pathological factors of various cancers is still widely debated.Meta-analysis is a statistical method that uses the statistical formulas of the relevant literature to perform a second analysis.It effectively synthesizes the data in each literature and improves the statistical effectiveness of the conclusions.In addition,meta-analysis can also analyze the sources of heterogeneity among sub-groups,which has guiding significance for our future research.In this paper,we collected a total of 73 papers related to c-Met gene expression and prognosis of solid tumors from the PubMed database.Meta-analysis shows that there is significant statistical heterogeneity in the overall survival rate(OS)among patients with solid tumors between studies(I~2=76%,P<0.01,HR=1.47,95%CI=1.31–1.65,and P<0.01).There is also statistical heterogeneity in the disease-free survival(DFS)of solid tumor patients(I~2=85%,P<0.01,HR=2.12,95%CI=1.49-3.03.and P<0.01).However,the analysis of the disease-free survival rate has obvious publication bias.Therefore,over-expression of c-Met cannot be used as an index to determine the disease-free survival of patients with solid tumors.According to the type of cancer,we divided the study into 7groups for controlled studies.The results showed that the overexpression of c-Met has a significant correlation with the poor prognosis of many cancers.Only liver cancer did not show a significant correlation.