Meta-analysis On Efficacy And Safety Of Cediranib Involved Regimen For Advanced Solid Tumors

AIM:To evaluate the efficacy and safety of cediranib involved regimen in patients with advanced solid tumors by meta-analysis.METHODS: Publications were searched from Pub Med,Cochrane Library,EMBase,ASCO Abstract,Wanfang,CNIK,and VIP.Randomized controlled trials focusing on cediranib involved regimen for advanced solid tumors were collected.According to the inclusion and exclusion criteria,literatures were screened,data of the included studies were extracted and the methodological quality were evaluated.The meta-analysis were performed using the software Revman 5.3.Outcome analysis were progression-free survival(PFS),overall survival(OS),objective response rate(ORR)and grade?3 adverse effect.RESULTS:A total of 9 randomized controlled trials involving 6 types of solid tumors and 2345 patients were included.The results of the meta-analysis showed that compared to non-cediranib regimen,cediranib involved regimen resulted in significant benefit in PFS(HR=0.78,95%CI:0.71-0.85,P<0.00001).however,there were no significant difference in OS(HR=0.91,95%CI:0.81-1.02,P=0.12)or ORR(RR=1.21,95%CI :0.97-1.51,P=0.09)between the two groups.In terms of grade?3 adverse effect,the analysis showed a statistically significant increase in diarrhea(RR=4.06,95%CI:2.97-5.54,P<0.00001),fatigue(RR=1.91,95%CI:1.49-2.54,P<0.000 01),hypertension(RR=3.55,95%CI:2.54-4.96,P< 0.00001),anorexia(RR=4.05,95%CI : 2.31-7.07,P < 0.00001),neutropenia(RR=1.31,95%CI:1.14-1.50,P=0.0002),leukopenia(RR=1.63,95%CI:1.09—2.43,P=0.02)and thrombocytopenia(RR=1.68,95%CI:1.31-2.14,P < 0.0001).However,there were no significant difference in peripheral sensory neuopathy(RR=1.42,95%CI:0.91-2.23,P=0.12),anemia(RR=1.13,95%CI : 0.51-2.47,P=0.77)and nausea(RR=1.46,95%CI:0.56-3.77,P=0.44).CONCLUSION:Cediranib involved regimen could improve PFS of patients with advanced solid tumors,but it yielded no improvement in OS or ORR.Cediranib involved regimen also could increase the risk of adevse effect.