| Background/AimsA Elevated pre-treatment plasma D-dimer level has been reported as a indicator associated with a poor prognosis in several types of malignancies.The aim of this meta-analysis we performed was to determine the association of elevated plasma D-dimer levels and long term survival in solid cancers,including nasopharyngeal carcinoma,melanoma,renal cell carcinoma,esophageal squamous cell carcinoma,lung cancer,endometrial cancer,gastric cancer,ovarian cancer,cervical cancer,sarcoma,and colorectal cancer.MethodsAll eligible publications have been searched from PubMed and Web of Science Databases up to July 2017.Overall survival(OS)was regarded as primary outcome and 1-year survival rate,3-year survival rate and 5-year survival rate were chosen as secondary outcomes.Relative risk(RR)and hazard ratio(HR)with its 95%confidence interval(CI)were extracted and analyzed.Results16 studies with 3186 patients were included in our meta-analysis.The evidence showed that pooled analysis showed that patients with a high plasma D-dimer level had a worse prognosis than patients with a low plasma D-dimer level(HR=2.08,95%CI 1.89-2.29,P=0.59).Additionally,cancer patients with high D-dimer demonstrates a much lower1-year survival rate(RR=2.87,95%CI =2.08-3.96,P =0.003),3-year survival rate(RR=2.32,95%CI =1.71-3.16,P<0.00001)and 5-year survival rate than those with low D-dimer levels(RR=1.94,95%CI =1.61-2.34,P<0.00001).ConclusionsThe plasma D-dimer level could be a prognostic biomarker of solid cancer patients. |
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